三组分[3+2+1]杂环化合成1,3,5-三嗪衍生物

Three-component[3+2+1]heteroannulation for the synthesis of 1,3,5-triazine derivatives

在微波辐射下,以乙二醇为溶剂,碳酸铯为碱促进剂,将芳甲脒和醛以物质的量之比2∶1反应,合成了一系列1,3,5-三嗪衍生物.该方法具有反应时间短（22～30min）、操作简单和环境友好等优点.产物经红外光谱、核磁共振氢谱、质谱表征,2-对甲苯基-4,6-二苯基-1,3,5-三嗪的结构经单晶X射线衍射分析予以确证.

Using ethane-1,2-diol as solvent and Cs2CO3 as base promoter,a series of 1,3,5-triazine derivatives were synthesized via a three-component reaction of aryl carboximidamide and aldehydes with the the ratio of amount of substance 2∶1under microwave irradiation.This method has the advantages of short reaction times（22～30min）,simple operation and environment friendliness.The structures of the products were identified by IR,1 HNMR and HRMS.Furthermore,the compound 2-（4-methylphenyl）-4,6-diphenyl-1,3,5-triazine was confirmed by X-ray diffraction.