宁波发热伴血小板减少综合征流行病学监测结果分析

The results of the epidemiological surveillance of severe fever with thrombocytopenia syndrome in Ningbo City

目的了解宁波市发热伴血小板减少综合征(新布尼亚)流行状况。方法在宁波市2家县级医院和2家乡镇卫生院建立监测哨点,采用卫生部统一的诊断标准和个案调查表对发热伴血小板减少综合征病例进行调查,对监测区患者血清进行病毒分离培养和M基因序列测定分析。结果报告11例发热伴血小板减少综合征,死亡1例。156只蜱均未检测出携带新布尼亚病毒(SFTSV),检测健康人群血清265份,SFTSV抗体阳性率为6.14%;人群抗体阳性水平随着年龄的增加而增高(P<0.01)。5株宁波分离株与日本、舟山分离株亲缘关系较近,其核苷酸和氨基酸序列变异很小,序列相似性在96%以上。结论宁波市是发热伴血小板减少综合征(布尼亚病)的流行地区,应加强发热伴血小板减少综合征症状监测。

Objective To learn the epidemiological status of severe fever with thrombocytopenia syndrome（ SFTS）.Methods The surveillance sites were established in two county level hospitals and two township health centers in Ningbo city. Using the diagnostic criteria of the national ministry of health and questionnaire of epidemiological case survey,cases with SFTS were investigated. The SFTS virus was isolated with Vero cells from the positive serum and the gene sequence was analyzed. Results Eleven cases were reported during year 2012—2013,including one person died. A total of 156 ticks were detected negative. The positive rate of serum collected from healthy people in local area was 6. 14% and increased with age（ P〈0. 01）. There were a close relationship between five isolates of Ningbo and isolates of Japan and Zhoushan,and the gene sequence similarity was more than 96%. Conclusion SFTS cases were reported in Ningbo City,and the surveillance system should be strengthened especially for the disease detection.