固肾生发丸联合乌灵胶囊内服对斑秃T辅助细胞因子的影响

Influence of Gushen Shengfa Pills Combined Wuling Capsules on Th1/Th2 Cytokines in Patients with Alopecia Areata Disease

目的:探讨固肾生发丸联合乌灵胶囊内服治疗斑秃(肝肾不足证)的临床疗效及对Th1/Th2细胞因子的调控作用。方法:将120例患者采用随机按数字表法分为对照组和观察组各60例。两组均外用米诺地尔酊,对照组口服复方甘草酸苷片,3片/次,3次/d;和复方胱氨酸片,2片/次,3次/d;观察组口服固肾生发丸,2.5 g/次,3次/d;和乌灵胶囊,3粒/次,3次/d。2组疗程均为3个月。对脱发面积及部位、轻拉发试验及毛发生长情况进行治疗前后的评分,进行治疗前后采用匹兹堡睡眠质量指数(PSQI)评分,检测治疗前后血清干扰素-γ(IFN-γ),白细胞介数-12(IL-12),IL-4和IL-10水平。结果:经Ridit分析,观察组疗效优于对照组(P<0.05);治疗后观察组脱发面积及部位、轻拉发试验及毛发生长情况等主要症状、体征和PSQI评分均低于对照组(P<0.01);与健康组比较,治疗前两组IFN-γ和IL-12水平均升高,IL-4和IL-10水平均下降(P<0.01);治疗后观察组IFN-γ和IL-12水平低于对照组,IL-4和IL-10水平高于对照组(P<0.01)。结论:固肾生发丸和乌灵胶囊内服能改善睡眠质量、调节Th1/Th2趋于平衡、促进头发的生长,其临床疗效优于复方甘草酸苷片和复方胱氨酸片联用。

Objective： To discuss the clinical effects of Gushen Shengfa pills combined Wuling capsules in treating alopecia areata disease with deficiency of liver and kidney symptoms and to investigate its regulatory effect on Thl/Th2 cell factor. Method： One hundred and twenty patients were randomly divided into the control group （60 cases） and the observation group （60 cases） by digital method. Patients in the two groups received minoxidil tincture for external use. Patients in the control group added 3 pieces of compound glycyrrhizin tablets and 2 pieces of compound cystine tablets thrice daily. Patients in the observation group added 2.5 g Gushen Shengfa pills and 3 pieces of Wuling capsules thrice daily. All patients received 3 months of treatment. Another 15 healthy subjects were assigned to the healthy group. Scores of hair loss area and position, light pull hair test and hair growth were conducted before and after therapy. Besides, Pittsburgh sleep quality index （PSQI） scores were conducted. Levels of serum interferon-γ （IFN-γ）, interleukin-12 （IL-12）, IL-4 and IL-10 were tested. Result： The curative effect in the observation group was superior to that in the control group （P 〈 0.05）. The main symptoms scores including hair loss area and position, light pull hair test and hair growth, and the signs and PSQI scores in the observation group were lower than those in the control group after treatment （P 〈 0.01 ）. Compared with the healthy group, levels of IFN-T and IL-12 were higher, the IL-4 and IL-10 levels were lower in both the two groups before treatment （P 〈 0.01 ）. After therapy, IFN-γ and IL-12 levels decreased, IL-4 and IL-10 levelsincreased in the observation group, the results were better than those in the control group （P 〈 0.01 ）. Conclusion： Gushen Shengfa pills combined Wuling capsules could improve the quality of sleep, control the Thl/ Th2 balance, promote the growth of hair. Its clinical effect is superior to the treatment of compound glycyrrhizin tablets combined with compound cystine tablets.