阿托伐他汀钙片联合胺碘酮治疗慢性心力衰竭并室性心律失常的疗效

Curative effect analysis of atorvastatin calcium tablets combined with amiodarone in the treatment of chronic heart failure with ventricular arrhythmia

目的探讨阿托伐他汀钙片联合胺碘酮治疗慢性心力衰竭(CHF)并室性心律失常的疗效。方法将81例CHF并室性心律失常患者分成两组,均给予常规治疗,对照组加用胺碘酮,观察组加用阿托伐他汀钙片和胺碘酮,观察两组的疗效、心电图和心功能变化,以及部分细胞因子水平。结果观察组疗效明显,总有效率与对照组比较差异有统计学意义(P<0.05)。观察组LVEF、6MWT均明显高于对照组,差异有统计学意义(P<0.05)。观察组BNP、Hs-CRP水平明显低于对照组,两组比较差异均有统计学意义(P<0.05)。无明显不良反应。结论阿托伐他汀钙片联合胺碘酮对CHF并室性心律失常患者的临床疗效较好,且安全性高。

Objective To investigate the curative effect of atorvastatin calcium tablets combined with amiodarone on chronic heart failure（ CHF） with ventricular efficacy arrhythmia. Methods Eighty-one cases of CHF with ventricular arrhythmia were divided into two groups and given conventional treatment. On this base,the control group were given amiodaron,and the observation group were given amiodaron and atorvastatin calcium tablets. The curative effect,electrocardiogram and heart function,and cytokine levels were compared. Results Curative effect in the observation group was obvious,and the total efficiency in the observation group was significantly higer than that in the control group（ P 〈0. 05）. In the observation group,LVEF,6MWT were significantly higher than those in the control group,and the differences were statistically significant（ P 〈0. 05）. The levels of Hs-CRP and BNP were significantly lower than those of the control group,and the differences were significant between the two groups（ P 〈0. 05）. There was no obvious adverse reaction. Conclusion The clinical efficacy of atorvastatin calcium tablets combined with amiodarone on CHF patients with ventricular arrhythmias is better and it is safe.