糖皮质激素辅助用于急性加重期慢阻肺对患者动脉血气指标的影响分析

Effect of glucocorticoid on aterial blood gas indexes in patients with acute exacerbation of chronic obstructive pulmonary disease

目的分析急性加重期慢阻肺治疗中应用糖皮质激素的效果及对患者动脉血气指标的影响。方法选取我院2011年1月至2013年12月间收治的急性加重期慢阻肺患者84例,随机分为对照组和观察组,对照组给予特布他林,观察组在对照组基础上给予丙酸氟替卡松气雾剂,比较两组治疗效果。结果观察组治疗总有效率95.24%,明显高于对照组的73.81%;治疗后患者FEV1/FVC、FEV1预计值、PEF改善程度均明显优于对照组;PaO2、PaCO2指标结果优于对照组(P均<0.05)。结论急性加重期慢阻肺治疗中加用糖皮质激素可有效改善患者肺功能及动脉血气指标,提高治疗效果,值得临床推广应用。

Objective To analyze the effect of glucocorticoid on acute exacerbation of chronic obstructive pulmonary disease（ COPD） period and its effect on blood gas indexes. Methods Eighty-four patients with acute exacerbation of COPD who were admitted in our hospital from 2011 January to 2013 December were selected and randomly divided into control group and observation group.The control group was given terbutaline,and the observation group were given Fluticasone Propionate Aerosol extra besides the drug of control group based. The treatment effects of the two groups were compared. Results The total effective rate of treatment group was 95. 24%,which was significantly higher than that of control group（ 73. 81%）. The FEV1 / FVC,FEV1 and PEF change of patients significantly better improved than the control group after treatment; the effect of Pa O2,Pa CO2 improvements were also better than that of control group（ P〈 0. 05）. Conclusion Applying glucocorticoid in the treatment of COPD can effectively improve the pulmonary function and arterial blood gas index and enhance the therapeutic effect,so it is worthy of clinical application.