头孢他啶雾化治疗老年慢性支气管炎急性发作疗效观察

Observation of Ceftazidime Inhalation in Treatment of Ederly Patients with Acute Exacerbation of Chronic Bronchitis

目的:观察头孢他啶雾化吸入治疗医院内老年慢性支气管炎急性发作的临床疗效。方法:≥80岁的慢性支气管炎急性发作住院患者48例随机分为观察组与对照组(n=24)。在常规解痉平喘、化痰治疗基础上,对照组予头孢他啶1.0 g加0.9%氯化钠注射液100 ml,ivd q12h;观察组予头孢他啶1.0 g加0.9%氯化钠注射液10 ml,雾化吸入q12h。均治疗7 d。观察两组患者临床症状、体征改善情况,血常规及C-反应蛋白(CRP)水平变化,比较两组临床疗效。结果:治疗后,两组患者症状及体征消失时间以及总有效率等比较,差异均无统计学意义(P>0.05)。治疗后两组患者的白细胞总数、中性粒细胞比值、CRP等均较治疗前显著下降(P<0.05),治疗后两组患者的白细胞总数、中性粒细胞比值及CRP比较,差异无统计学意义(P>0.05)。结论:头孢他啶雾化吸入治疗医院内老年慢性支气管炎急性发作效果显著,与静脉注射给药疗效相当,值得推广应用。

Objective： To observe the clinical effect of ceftazidime inhalation in treatment of elderly patients in hospital with acute exacerbation of chronic bronchitis. Methods： 48 cases of Hospitalized patients with acute exacerbation of chronic bronchitis over 80 years were randomly divided into observation group and control group（ n = 24）. They all were given conventional antispasmodic,expectorant treatment. The observation group was given ceftazidime inhalation,and the control group ceftazidime administered intravenously. The courses of treatment in two groups were 1 week. Symptoms and physical signs of the two groups were observed,the total effective rate of the two groups were compared. Results： Though the improvement degree of cough,expectoration,dyspnea and lung rale in two groups were significantly and the total number of white blood cells,neutrophils and C-reactive protein（ CRP） were reduced after treatment（ P〈0. 05）,the total effective rate of two groups was no significant difference（ P〉0. 05）. The total number of white blood cells,neutrophils ratio and CRP of patients in two groups were no statistical difference after treatment（ P〉0. 05）. Conclusion： The treatment of ceftazidime inhalation in elderly patients in hospital with acute exacerbation of chronic bronchitis is significant,and should be widely applied.