健胃消食口服液联合莫沙比利治疗儿童功能性消化不良疗效观察

The effect of Jianweixiaoshi Oral Liquid combined with Mosapride on pediatric patients with functional dyspepsia:a clinical observation

[目的]探讨健胃消食口服液联合莫沙比利治疗儿童功能性消化不良（FD）的临床疗效。[方法]选择2010年6月～2014年6月卢龙县下寨卫生院儿科收治的FD患儿84例作为研究对象,按照数字随机表法分为2组,每组42例,观察组采用健胃消食口服液联合莫沙比利治疗,对照组采用莫沙比利治疗,比较2组治疗前后主要症状评分和治疗有效率,并比较2组治疗前后血清胃泌素（GAS）和生长抑素（SS）水平。[结果]治疗前2组主要症状上腹痛、腹胀、厌食、早饱、反酸、恶心评分差异无统计学意义,治疗后2组上述指标均显著下降（P〈0.05）,观察组低于对照组（P〈0.05）,观察组总有效率高于对照组（P〈0.05）,2组血清GAS、SS水平治疗前差异无统计学意义,治疗后血清GAS水平均显著升高（P〈0.05）,观察组高于对照组（P〈0.05）,SS水平均显著降低,观察组低于对照组（P〈0.05）。[结论]健胃消食口服液联合莫沙比利治疗儿童FD疗效确切,安全性好,有临床推广价值。

[Objective]To investigate the curative effect of Jianweixiaoshi Oral Liquid（JOL）combined with Mosapride on pediatric patients with functional dyspepsia（FD）.[Methods]Eighty-four pediatric patients with FD in our center from June 2010 to June 2014 were selected,and divided into two groups according to the random number table,with 42 cases in each group.The observation group was administered with JOL combined with Mosapride,the control group received Mosapride only.The main symptom scores,effective rate and levels of serum gastrin（GAS）and somatostatin（SS）were compared before and after the treatment.[Results]Symptom scores of upper abdominal pain,bloating,anorexia,early satiety,acid regurgitation and nausea in two groups were of no statistical significance before the treatment,but significantly decreased after the treatment（P〈0.05）,score of the observation group was lower than that of the control group（P〈0.05）,and the total effective rate of the former was higher（P〈0.05）.There were no significant differences between two groups in serum GAS,SS levels before the treatment.The serum GAS levels were significantly increased after the treatment（P〈0.05）,which was higher in the observation group（P〈0.05）.The levels of SS significantly decreased,and it was lower in the observation group（P〈0.05）.[Conclusion]JOL combined with Mosapride improved FD with security in pediatric patient.It was worthy of clinical promotion.