我国高校潜在结核感染者进行预防性治疗效果的Meta分析

Meta analysis of potential TB infectors conducting preventive treatment effects in Chinese universities

目的评价预防性治疗对高校潜在结核感染者结核发病的影响。方法根据系统评价的原则制定检索策略,收集符合纳入标准的文献,提取数据并应用Rev Man 5.1软件进行分析。纳入对象为潜在结核感染者,对照组为空白组、干预组为异烟肼利福喷汀联用方案。合并统计量采用率差。结果 Meta分析结果显示:潜在结核感染者进行预防性治疗至少三个月后,合并后的结核发病率OR 95%CI为0.21(0.14,0.32),得出进行预防性治疗更有效的结论,与对比组有显著性差异。

Objective To investigate efficacy of preventive chemotherapy treatment for latent tuberculosis - infec- ted students of university in Chinese. Methods Search strategy was established according to the Cochrane sys- tematic review, related data of the articles metinclusion criteria was gathered, and meta analysis was per- formed using RevMan5. 1. Isoniazid plus is compared with the control group as the experimental group. Results The results of Meta - analysis shows that the merged incidence of tuberculosis OR 95% C1 is 0.21 （0. 14, 0.32） . When latent tuberculosis - infected students were treated with preventive chemotherapy for 3 months, and the efficacy of preventive chemotherapy treatment for latent infected students is much better than the one being taken none -preventive chemotherapy treatment.