血必净治疗毛细血管渗漏综合征的临床疗效分析

The clinical efficacy analysis of Xuebijing in treatment of capillary leak syndrome

目的:观察血必净注射液对毛细血管渗漏综合征(CLS)的治疗作用,并探讨其作用机制。方法:将60例临床诊断为CLS的患者随机分为对照组和血必净组。比较2组患者的血栓调节蛋白(TM)、血管性假血友病因子(vWF)、C反应蛋白(CRP)、血肌酐(Cr)、总胆红素(TBIL)、MACR、APACHEⅡ分值,以及2组患者机械通气时间、住院时间和总病死率。结果:治疗前2组指标比较差异均无统计学意义;血必净组第5、7天TM、vWF、MACR较对照组同期下降显著(P<0.05);血必净组机械通气时间、住院时间及总病死率均显著低于对照组(P<0.05);死亡组入院时APACHEⅡ评分及MACR均显著高于存活组。结论:血必净注射液对CLS有一定的疗效,保护血管内皮细胞可能是其对CLS的作用机制;MACR是判断病情严重性较为可靠的指标。

Objective：To observe the therapeutical effects of Xuebijing Injection on capillary leak syndrome（CLS）,and to explore its mechanism of action.Method：60cases of patients who were clinically diagnosed CLS were randomly divided into the control group and Xuebijing group.Comparing the TM,vWF,C reactive protein（CRP）,serum creatinine（Cr）,total Bilirubin（TBIL）,MACR,APACHE Ⅱ,mechanical ventilation time,hospitalization time and mortality of the two groups.Result：Before treatment there were no statistical significance in the indexes between the two groups.On day 5and 7the TM,vWF,MACR were declined significantly in Xuebijing group compared with control group（P〈0.05）.The mechanical ventilation time,hospitalization time and mortality of Xuebijing group were significantly lower than those in the control group（P〈0.05）.On admission the APACHEⅡ score and MACR of the dead patients were higher than those of survivors.Conclusion：Xuebijing injection has a certain effect on CLS.Protecting vascular endothelial cells may be the mechanism of CLS.MACR is a reliable index in judging the severity of the illness.