脓毒症液体复苏终点指标研究与限制性液体管理

Study of fluid resuscitation endpoint and restrictive fluid management on sepsis

在《严重脓毒症及脓毒性休克管理指南》（简称＂指南＂）中,液体复苏作为重要的治疗方案,通过循证医学证据不断完善,并在全球推广,严重脓毒症及脓毒性休克的病死率明显降低。但是,在临床实践中,由于积极的液体复苏导致液体过负荷,加重心、肺、肾等重要脏器损伤等因素的存在,导致脓毒性休克的病死率仍高达40%〔1〕。因此,对液体复苏终点的研究,成为目前脓毒症治疗领域的重点。

The fluid resuscitation is an important treatment in surviving sepsis campaign：international guidelines for management of severe sepsis and septic shock.It has been improved by evidence based medicine,spread the world,and has decreased the mortality of severe sepsis and septic shock patients.However,in clinical practice,aggressive fluid resuscitation leads to fluid overload,increases the important organs＇ damage,such as heart,lung,kidney,et al,so that the mortality of septic shock is still as high as 40%〔1〕.Therefore,the research on fluid resuscitation endpoint,becomes the focus of the field in the treatment of sepsis.