S100钙结合蛋白A13和人成纤维细胞生长因子-1在甲状腺肿瘤中的表达及临床意义

S100 calcium binding protein A13 and fibroblast growth factor-1 expression and clinical significance in thyroid tumors

目的 检测S100钙结合蛋白A13（S100A13）和人成纤维细胞生长因子-1（FGF-1）在甲状腺癌、甲状腺腺瘤、正常甲状腺组织中的表达,探讨两者与甲状腺癌发生发展的关系.方法 采用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶（SP）方法检测甲状腺癌、甲状腺腺瘤、正常甲状腺组织中两者的表达,比较两者在两种不同组织中的表达.结果 甲状腺癌组织中,S100A13的表达阳性率为93.3％（56/60）,在甲状腺腺瘤组织中S100A13的表达阳性率为66.7％ （20/30）,在正常甲状腺组织中的表达阳性率为60.0％（12/20）,S100A13在甲状腺癌组织的表达阳性率明显高于甲状腺腺瘤及正常甲状腺组织,差异有统计学意义（P＜0.05）,但是在甲状腺腺瘤及正常甲状腺组织中其表达差异无统计学意义（P＞0.05）;FGF-1在甲状腺癌组织中的表达阳性率为81.7％（49/60）,在甲状腺腺瘤组织中FGF-1的表达阳性率为63.3％（19/30）,在正常甲状腺组织中的表达阳性率为55.0％（11/20）,FGF-1在甲状腺癌组织的表达阳性率明显高于甲状腺腺瘤及正常甲状腺组织,差异有统计学意义（P＜0.05）,但是在甲状腺腺瘤及正常甲状腺组织中其表达差异无统计学意义（P＞0.05）;S100A13与FGF-1表达阳性与甲状腺癌的淋巴结转移相关（P＜0.05）.结论 S100A13与FGF-1与甲状腺癌的发生及发展密切相关.

Objective To detect S100 calcium binding protein A13 （S100A13） and fibroblast growth factor-1 （FGF-1） in thyroid cancer,thyroid adenoma and normal thyroid tissue,and to explore their relationship with the development of thyroid cancer.Methods Streptavidin avidin-peroxidase （SP） immunohistochemical method was used to detect the expression of S100A13 and FGF-1 in thyroid cancer,thyroid adenoma and normal thyroid tissues.Results The expression rate of S100A13 in thyroid cancer,thyroid adenoma and normal thyroid tissues was 93.3% （56/60）,66.7% （20/30） and 60.0% （12/20） respectively.The S100A13 expression rate in thyroid cancer and thyroid adenoma tissues was significantly higher than in normal thyroid tissue （P 〈 0.05）,but there was no significant difference between thyroid adenoma and normal thyroid tissues （P 〉 0.05）.The expression rate of FGF-1 in thyroid cancer,thyroid adenoma and normal thyroid tissues was 81.7% （49/60）,63.3% （19/30）,and 55.0% （11/20） respectively.The positive rate of FGF-1 expression in thyroid cancer tissues was significantly higher than that in thyroid adenoma and normal thyroid tissues （P 〈 0.05）,but there was no significant difference between thyroid adenoma and normal thyroid tissues （P〉 0.05）.The positive expression of S100A13 and FGF-1 was associated with lymph node metastasis （P 〈0.05）.Conclusion S100A13 and FGF-1 are closely related to the occurrence and development of thyroid cancer.