阿司匹林联合厄贝沙坦治疗对急性脑梗死患者的影响研究

Effect of Aspirin Combined with Irbesartan on Acute Cerebral Infarction

目的探讨阿司匹林联合厄贝沙坦治疗急性脑梗死的临床疗效及对血液流变学、血清高敏C反应蛋白(hs-CRP)水平、神经功能、生活质量的影响。方法选择韶关市第一人民医院2011年4月—2014年5月收治的急性脑梗死患者120例,采用随机数字表法分为对照组和观察组,每组60例。对照组患者单纯给予阿司匹林治疗,观察组患者给予阿司匹林联合厄贝沙坦治疗。观察两组患者临床疗效,治疗前后血液流变学、血清hs-CRP水平、神经功能缺损评分变化,出院后生活质量,治疗期间不良反应情况。结果观察组患者临床疗效优于对照组(P<0.05)。两组患者治疗前红细胞比容、全血低切黏度、全血高切黏度、血浆黏度、血清hs-CRP水平及神经功能缺损评分比较,差异均无统计学意义(P>0.05);观察组患者治疗后上述指标均低于对照组(P<0.05)。观察组患者出院后交流、行动能力、思维、手部功能、力量评分均高于对照组(P<0.05)。两组患者治疗期间均未出现明显不良反应。结论阿司匹林联合厄贝沙坦治疗急性脑梗死的临床疗效确切,安全性较高,可有效改善血液流变学、减轻炎性反应、提高神经功能及生活质量。

Objective To investigate the clinical effect of aspirin combined with irbesartan on acute cerebral infarction and its impact on hemorheology, serum high -~ sensitivity C - reactive protein （hs - CRP） level, neural function, quality of life. Methods From April 201! to May 2014, 120 acute cerebral infarction patients were selected in the First People＇s Hospital of Shaoguan, and they were divided into control group and observation gmmp according to random number table, each of 60 cases. Control group given asp/fin, observation group given aspirin combined with irbesartan. Clinical effect, hemorheology, serum hs - CRP level, neurological function deficit score, quality of life after discharge, incidence of adverse reactions during treatment, Results Clinical effect of observation group was better than that of control group （ P 〈 0. 05 ）. No significant differences was found of hematocrit value, }ow blood viscosity, high blood viscosity, plasma viscosity, serum hs - ClIP level and neurological function deficit score between the two groups before treatment （P 〉 0. 05 ）, but above index of observation group were lower than those of control group （ P 〈 0. 05 ）. After discharge, communication ability score, action capability score, thinking score, hand function score, power score of observation group were higher than those of control group （ P 〈 0. 05 ）. No one of the two groups occurred obvious adverse reactions during treatment. Conclusion Aspirin combined with irbesartan has certain clinical effect and safety on acute cerebral infarction, can improve the hemorheology neurological function and quality of life, reduce the inflammatory reaction.