摘要
目的探讨瑞舒伐他汀钙强化降脂对颈动脉粥样硬化的影响。方法选取2012年1月—2014年3月武进中医院收治的90例颈动脉粥样硬化患者,随机分为对照组、治疗组和强化组,各30例。在阿司匹林治疗基础上,治疗组加入瑞舒伐他汀钙10mg/d,强化组加入瑞舒伐他汀钙20mg/d,对照组给予安慰剂。连续治疗6个月后比较临床疗效。结果治疗前后治疗组和强化组TC、TG、HDL-C和LDL-C比较,差异有统计学意义(P<0.05);治疗后强化组TC、TG、LDL-C低于治疗组,HDL-C高于治疗组,差异有统计学意义(P<0.05)。与治疗前比较,治疗后治疗组和强化组颈动脉斑块面积和颈动脉内膜-中膜厚度(CIMT)减少,差异有统计学意义(P<0.05);且强化组颈动脉斑块面积和CIMT小于治疗组,差异有统计学意义(P<0.05)。结论瑞舒伐他汀钙强化降脂可有效的调脂,有助于减少斑块面积。
Objective To explore the influence of rosuvastatin calcium intensive lipid-lowering on carotid atherosclerosis. Methods A total of 90 patients with carotid atherosclerosis were chonsen in Wujin Hospital of Traditional Chinese Medicine of Changzhou from January 2012 to March 2014,and then they were randomly divided into control group,treatment group and intensive lipid-lowering group,30 cases in each group. On the basis of aspirin,patients of treatment group were treated with rosuvastatin calcium（ 10 mg / d）,intensive lipid-lowering group were treated with rosuvastatin calcium（ 20 mg / d）,while patients of control group were treated with placebo. After 6 months of treatment,the lipid-lowering effect were compared.Results Compared with those index before treatment,TC,TG,LDL-C were significantly lower and LDL-C were significantly higher of treatment group and intensive lipid-lowering group after treatment（ P 〈0. 05）; after treatment,TC,TG,LDL-C of intensive lipid-lowering group were lower than those of treatment group,HDL-C was higher than that of treatment group（ P 〈0. 05）. Compared with those index before treatment,carotid intima-media thickness（ CIMT） and carotid plaque area of treatment group and intensive lipid-lowering group were significantly smaller after treatment（ P 〈0. 05）; after treatment,CIMT and carotid plaque area of intensive lipid-lowering group were significantly smaller than those of treatment group（ P 〈0. 05）. Conclusion Rosuvastatin calcium intensive lipid-lowering can effectively lower blood lipids and reduce plaque area.
出处
《临床合理用药杂志》
2015年第3期5-6,共2页
Chinese Journal of Clinical Rational Drug Use
