甲状腺功能异常与脑出血急性期出血量的相关性分析

The correlation analysis of abnormal thyroid function and the bleeding volume with acute intracerebral hemorrhage

目的探讨甲状腺功能异常与脑出血急性期出血量的相关性。方法将220例脑出血急性期患者根据患者有无甲状腺功能异常分为试验组(甲状腺功能异常组)和对照组(甲状腺功能正常组)各110例。要求所有患者接受控制血压、维持呼吸道通畅、保护脑细胞、脱水降颅压以及维持电解质平衡等针对急性脑出血的常规治疗。常规化验2组患者的血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离T3(FT3)、游离T4(FT4)、促甲状腺激素(TSH)水平,比较2组患者出血及预后情况。结果脑出血急性期试验组患者血清T3、FT3水平明显低于对照组,血清T4、FT4、TSH明显高于对照组,差异均有统计学意义(P<0.05)。试验组中大量出血者明显多于对照组,而小量出血者明显少于对照组(P均<0.05)。试验组患者平均出血量显著高于对照组,病死率高于对照组,痊愈率显著低于对照组(P均<0.05)。此外,试验组中甲状腺功能轻度异常者和重度异常者除在小量出血一项上无明显差异外,其余各项差异明显(P<0.05)。结论甲状腺功能异常与脑出血患者的病情程度明显相关,重度异常患者出血量多,病死率高。

Objective To analysis the correlation of abnormal thyroid function and the bleeding volume with acute in- traeerebral hemorrhage. Methods 220 cases patients with acute intracerebral hemorrhage were randomly divided into test grou and control group, each of 110 cases. 110eases were treated by conventional treatment. Assay the T_3, T_4, FT_3, FT_4 and TSH of 2 groups. Compared the bleeding and prognosis. Results The T3 , FT3 of test group was lower than that of control group, T_4, FT_4, TSH was higher than that of control group, the difference was statistically （ P 〈 0.05 ）. The number of heave bleeding patients was higher than that of control group, the number of small bleeding patients was less than that of control group（ P 均 〈 0.05 ）. The average bleeding volume of test group was higher than that of control group, mortality was higher than that of control group, cure rate was less than that of control group,the difference was statistically significant （ P 均 〈 0.05 ）. The difference of small bleeding in mildly abnormal thyroid function and severe abnormalities has statistically significant （ P 〈 0.05 ）. Conclusion Abnormal thyroid function is obviouslyrelated with the severity of cerebral hemorrhage. The severe bleeding patients with large bleeding and high mortality.