小儿病毒性脑炎与血清IL-1、TNF-α水平的相关性分析

Correlation analysis of the level of serum IL-1,TNF-α and viral encephalitis in children

目的分析小儿病毒性脑炎与血清IL-1、TNF-α水平的相关性。方法选取60例病毒性脑炎患儿,进行综合治疗并应用纳洛酮联合更昔洛韦治疗,分别检测患儿急性期与治疗后血清IL-1、TNF-α的水平,同时选取60例健康者作为对照组,进行比较分析。结果重症组及轻症组病毒性脑炎患儿急性期血清IL-1、TNF-α水平均显著高于对照组,且重症组明显高于轻症组,差异均有统计学意义(P<0.05)。治疗后重症组及轻症组患儿血清IL-1、TNF-α水平均较治疗前显著降低,且治疗后重症组患儿血清IL-1、TNF-α水平仍高于轻症组患儿,差异均有统计学意义(P<0.05)。结论病毒性脑炎患儿血清中IL-1、TNF-α水平均显著提高,其水平能够反应疾病的发生、发展及治疗情况。

Objective To analyse the correlation of the level of serum IL-1 ,TNF-α and viral encephalitis in children. Methods 60 children with viral encephalitis were selected, 18 cases of children with severe symptoms as severe group and 42 eases with mild symptoms as mild group. All the viral encephalitis children treated with naloxone combined with ganciclovir. As well as ,60 healthy persons were selected as control group, the level of serum IL-1 ,TNF-α in childrenof control group and viral encephalitis children in acute period and after treatment were measured. Results The level of serum IL-1 ,TNF-α of viral en- cephalitis in children with acute period were significantly higher than that of the control group, and those indexes of severe group was higher than that of mild group, and the differences were statistically significant （P 〈 0.05 ）. After treatment, The level of serum IL-1 ,TNF-α of severe group and mild group both reduced,but those indexes of severe group still higher than that of mild group, the differences were statistically significant（ P 〈 0. 05 ）. Conclusion The level of serum IL-1, TNF-α in Children with viral encephalitis increase significantly, and the level of that indexes can reflect the occurrence, development and treatment of diseases.