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趋化因子受体CCR4和CCR7在三阴性乳腺癌组织中的表达及与临床预后的相关性 被引量：2

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摘要 目的研究趋化因子受体CCR4和CCR7在三阴性乳腺癌组织中的表达及与临床预后的相关性。方法选取58例三阴性乳腺癌患者及58例乳腺增生患者,采用免疫组化技术检测标本中CCR4和CCR7的表达情况,并分析其与患者的临床病理之间的关系。结果三阴性乳腺癌患者中CCR4和CCR7高表达均显著多于乳腺增生患者(P均<0.05),且CCR4和CCR7两者的表达呈显著正相关(r=0.614,P<0.05)。CCR4表达阳性者总生存率显著低于CCR4蛋白表达阴性者(P<0.05)。CCR7表达阳性者总生存率低于CCR7蛋白表达阴性者,差异有统计学意义(P<0.05),CCR4的表达与肿瘤分期、腋窝淋巴结转移、远处转移有关(P<0.05),CCR7的表达与腋窝淋巴结转移、淋巴结转移个数有关(P<0.05)。CCR4与CCR7高表达患者内脏转移与骨转移率比较差异无统计学意义(P>0.05)。结论趋化因子受体CCR4和CCR7在三阴性乳腺癌组织中呈现高表达,两者呈负相关关系,可应用于临床诊治三阴性乳腺癌患者和判断预后。
作者 张春侠 王妍 章来长 张晓元 赵胤铭
机构地区 空军航空医学研究所附属医院
出处 《现代中西医结合杂志》 CAS 2015年第6期618-620,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词 CCR4 CCR7 三阴性乳腺癌
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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共引文献74

同被引文献22

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现代中西医结合杂志
2015年 第6期

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