银杏叶提取物对突发性耳聋患者免疫功能的影响及疗效观察

Effects of Ginkgo Biloba Extract on Immune Function in Patients with Sudden Hearing Loss and Observation of Clinical Efficacy

目的探讨银杏叶提取物对突发性耳聋(sudden hearting loss,SHL)患者免疫功能的影响及其疗效。方法选取在我院诊治的SHL 124例,随机分为观察组和对照组各62例,两组均予基础治疗,观察组在基础治疗基础上予银杏叶提取物注射液治疗,观察比较两组治疗前后血清免疫功能指标及疗效。结果治疗后两组血清T细胞亚群中CD3、CD4百分比及IgG、IgM均较治疗前升高,差异有统计学意义(P<0.05);治疗后观察组血清T细胞亚群中CD3、CD4百分比及IgG、IgM均高于对照组,差异亦有统计学意义(P<0.05)。治疗后观察组有效率及总有效率均高于对照组,无效率低于对照组,差异均有统计学意义(P<0.05)。结论银杏叶提取物能改善SHL患者免疫功能,且治疗SHL效果较好。

Objective To investigate the effects of ginkgo biloba extract in the treatment of patients with sudden hearing loss and its influence on immune function. Methods A total of 124 cases of sudden hearing loss in our hospital were selected and were randomly divided into observation group and control group,with 62 cases in each group. The patients in the two the groups were given basic treatment. The patients in observation group were additionally given ginkgo biloba extract. The curative efficacy and immune function indicators were observed and compared between the two groups before and after treatment. Results After treatment,CD3,CD4,IgG,IgM levels of serum T cell subsets of patients in the two groups were higher than that before（P〈 0. 05）,and these indicators in the observation group were significantly higher than that in the control group（P〈 0. 05）. The total efficacy rate and efficacy rate of the observation group were obviously higher than that of the control group after treatment; the inefficiency rate in the observation group was significantly lower than that of control group. The difference was statistically significant（P〈 0. 05）. Conclusion The ginkgo biloba extract has reliable and stable curative effect on sudden hearing loss and can improve the immune function of patients of sudden hearting loss.