奥沙利铂加氟尿嘧啶治疗晚期食管癌的临床观察

Study of Oxaliplatin Combination with Fluorouracil in Treatment of Advanced Esophageal Carcinoma

目的探讨奥沙利铂加氟尿嘧啶在晚期食管癌中的治疗价值。方法将我院收治的60例晚期食管癌患者按照治疗方法的不同分为观察组和对照组,对照组给予顺铂、亚叶酸钙联合氟尿嘧啶治疗,观察组给予奥沙利铂、亚叶酸钙联合氟尿嘧啶,比较两组患者的近期疗效、不良反应以及生活质量。结果观察组的总有效率为43.3%,对照组的为40.0%,无统计学意义(P>0.05)。两组的中位进展时间也无统计学意义(P>0.05)。但观察组在恶心、呕吐、腹泻等不良反应的发生率显著低于对照组,生存质量显著高于对照组(P<0.05)。结论奥沙利铂加氟尿嘧啶治疗晚期食管癌疗效满意,不良反应较少,是较为安全有效的化疗方案。

Objective To investigate the treatment value of oxaliplatin combination with 5-FU therapy in the treatment of advanced esophageal cancer. Methods 60 cases of advanced esophageal cancer patients were divided into the observation group and the control group according to the different treatment methods, while the control group was given cisplatin, leucovorin and fluorouracil in the treatment, the observation group was given oxaliplatin, leucovorin, fluorouracil; clinical efficacy, adverse reaction and life quality were compared between two groups. Results The total effective rate in the observation group was 43.3% that had no statistical significance with 40% in the control group（P〉0.05）. The median time to progression between two groups have no statistical significance（P〉0.05）. But the incidence of side reaction, nausea, vomiting, diarrhea in the observation group was significantly lower than that in the control group, the life quality was significantly higher than that in the control group（P〈0.05）. Conclusion The curative effect of oxaliplatin combined with 5-FU in treatment of advanced esophageal cancer is less side reaction, chemotherapy; it is a safe and effective.