哌替啶联合阿托品在治疗急性心肌梗死中的应用

Combined Use of Meperidine and Atropine in Treatment of Acute Myocardial Infarction

目的探究与分析哌替啶联合阿托品在治疗急性心肌梗死中的应用。方法选取本院2011年1月至2012年12月收治的急性心肌梗死患者作为临床研究对象,随机分为对照组和试验组,对照组患者采取哌替啶治疗,试验组患者采取哌替啶联合阿托品治疗,观察患者疼痛时间及发生恶心,呕吐等并发症的情况。结果用药后,试验组患者的疼痛时间较对照组患者时间明显缩短,P<0.05,差异具有统计学意义。试验组出现恶心、呕吐等不良反应的人数显著低于对照组,P<0.05,差异具有统计学意义。两组患者出现过敏性休克及药物成瘾性的人数无显著性差异,P>0.05。结论哌替啶联合阿托品在治疗急性心肌梗死过程中疗效明显,能够显著缩短患者发作时疼痛的时间,有利于减少止痛药的成瘾性,且安全性较高,并在一定程度上减轻了患者的痛苦。

Objective To explore and analysis the application of combined use of meperidine and atropine in treatment of acute myocardial infarction.Methods Patients with acute myocardial infarction hospitalized from January 2011 to December 2012 in our hospital were selected as the clinical objects of my study,and were divided into two groups randomly,one control group and one experimental group.The patients of the control group took meperidine treatment while the patients of the experimental group took meperidine in combination with atropine.Results After medication,the pain time of the patients of the experimental group was significantly shorter than that of the patients in the control group,with P〈0.05.Adverse reactions such as nausea and vomiting of the experimental group was significantly lower than that of the control group,P〈0.05; Anaphylactic shock occurred in both groups,and there was no significant difference in anaphylactic shock and the number of drug addiction between these two groups,P〉0.05.Conclusions Obvious curative effect was identified in the treatment of acute myocardial infarction with meperidine and atropine.Combined use of meperidine and atropine can significantly shorten the pain time with high security,the discomfort of the patients and drug addiction can also be reduced to a certain extent.