雾化吸入利多卡因治疗慢性喘息型支气管炎急性发作的临床疗效

Clinical Effect of Atomization Inhalation of Lidocaine for Treatment of Acute Attack of Chronic Asthmatic Bronchitis

目的研究利多卡因雾化吸入用于治疗慢性喘息型支气管炎发作的临床疗效与意义。方法随机选取就诊于我院儿科慢性喘息型支气管炎急性发作患儿100例。分组为联合组、普通组,各50例。其中为普通组患者进行常规治疗;联合组给在常规治疗基础上联合雾化吸入利多卡因。比较两组患者经过不同治疗后总有效率、血气分析等指标。结果两组患者不同治疗后总有效率的比较,显示治疗后联合利多卡因雾化吸入患者总有效率为100%,显著优于常规治疗组78%(P<0.05),联合组治疗效果较好;治疗前后血气分析值比较显示联合组与普通组治疗前血气分析值无显著差异(P>0.05)。治疗后联合组血气分析值变化显著优于普通组(P<0.05)。结论雾化吸入利多卡因治疗慢性喘息型支气管炎疗效显著。短时间内能够有效抑制平滑肌收缩,降低气道高反应性,显著缓解患儿喘息现象。另外还能够减轻水肿及炎性反应,可有效控制支气管炎急性发作。

Objective To discuss and study the clinical effect and significance of atomization inhalation of lidocaine for treatment of acute attack of chronic asthmatic bronchitis.Method Randomly selected patients in pediatric acute episode of chronic asthmatic bronchitis in 100 cases and divided into combination group and common group both with 50 cases.Common group was given routine treatment and combination group was given atomization inhalation of lidocaine on basis of routine treatment.After different treatments,total effective rate and blood gas analysis of the 2 groups were compared.Result Total effective rate of combination group was 100% obviously higher than common group 78%（P〈0.05）.Changes of blood gas analysis of combination group were obvious superior to common group（P〈0.05）.Conclusion Atomization inhalation of lidocaine for treatment of acute attack of chronic asthmatic bronchitis has significant clinical effect.It can effectively restrain smooth muscle contraction,reduce bronchial hyperresponsiveness and obviously relieve breathing phenomenon of patients within a short time.Besides,it can also relieve edema and inflammatory reaction,and effectively control acute attack of bronchitis.