低钠血症与肝硬化Child-Pugh评分及并发症的相关性研究

Correlation study on hyponatremia with complications and Child-Pugh score in cirrhotic patients

目的探讨失代偿期肝硬化患者血清钠水平与Child-Pugh评分及其并发症的相关性。方法选取116名失代偿期肝硬化患者,根据其入院时血清钠水平将其分为正常组40例,轻度低钠组38例,中度低钠组23例以及重度低钠组15例,分析肝硬化患者不同血清钠水平与Child-Pugh评分及并发症发生率的关系。结果除消化道出血外,血清钠水平越低,肝肾综合征、肝性脑病和自发性腹膜炎的发生率均高,患者Child-Pugh评分越高,血清钠水平与Child-Pugh评分(r=-0.886,P=0)呈负相关。结论低钠血症与肝硬化患者的Child-Pugh评分及并发症的发生密切相关,通过测定肝硬化患者血清钠水平可有效判断患者病情的进展。

Objective To explore the correlation of serum sodium to complications and Child-Pugh score in patients with end-stage liver cirrhosis disease .Methods 116 patients with end-stage liver cirrhosis in our hospital were selected to be analyzed .They were divided into four groups , according to the levels of serum sodium：a normal group （n=40）, a mild hyponatremia group （n=38）, a moderate hyponatremia group （n=23） and a severe hyponatremia group （ n =15）.Child-Pugh score and complications were compared among different groups .Results Except for gastrointestinal bleeding , levels of serum sodium were associated with significantly higher incidences of other complications , such as hepatorenal syndrome , hepatic encephalopathy , spontaneous bacterial peritonitis , and higher Child-Pugh score （P〈0.05）.Serum sodium levels were negatively correlated with Child-Pugh score （r=-0.886, P=0）.Conclusions Hyponatremia is closely correlate with Child-Pugh score and complications in patients with liver cirrhosis disease .The levels of sodium can effectively predict the progression of a patient＆#39;s condition .