肿瘤微环境与肿瘤放射抵抗的研究进展

Research progress of relationship between tumor microenvironment and radioresistance

肿瘤细胞、基质细胞、免疫炎性细胞、细胞外基质及可溶性细胞因子等共同构成了肿瘤局部微生态环境。以往的研究主要集中于肿瘤细胞生物学行为、肿瘤细胞基因改变以及相关表型变化，而肿瘤的发生、发展以及对治疗的抵抗与肿瘤微环境密切相关。近年来的研究证实了肿瘤微环境是肿瘤组织的重要组成成员，其在肿瘤细胞的增殖、侵袭及扩散中发挥了不可替代的作用。文章对肿瘤微环境特点与其中的肿瘤相关巨噬细胞及肿瘤相关成纤维细胞等放射抵抗相关的研究进行介绍。

Tumor microenvironment is composed by tumor cells, stromal cells, immune-inflammatory cells, extracellular matrix, soluble cytokine and so on. Previous studies focused on the biological behavior, genetic changes and related phenotypic changes of tumor ceils, but tumor microenvironment is closely related with the tumor development and treatment resistance. In recent years, new studies have confirmed that tumor microenvironment is an important member of tumor, which play an important role in proliferation, invasion and proliferation of tumor cells. This article mainly introduces the tumor microenvironment features, tumor- associated macroDha~,e and tumor-associated fibroblasts, which led to the radioresistance of tumor.