自荧光支气管镜的临床应用观察

Observation of the clinical application of auto-fluorescence bronchoscopy

目的 观察分析自荧光支气管镜的临床应用情况.方法 选择行支气管镜检查患者224例（男190例,女34例）,按照随机数字表法分为观察组和对照组,对照组112例（男96例,女16例）,采用普通白光支气管镜检查;观察组112例（男94例,女18例）,采用普通白光支气管镜联合自荧光支气管镜检查.以原位癌和不典型增生病理活检阳性率及活检后出血情况作为主要观察终点,并对研究数据进行分析.结果 原位癌病理活检阳性率,观察组为3.1％,对照组为1.0％,差异有统计学意义（χ^2=19.761,P＜0.05）;不典型增生病理活检阳性率,观察组为13.2％,对照组为5.5％,差异有统计学意义（χ^2=21.426,P＜0.05）;活检后观察组应用止血药物种类及次数明显低于对照组,差异有统计学意义（F=9.574、12.763,均P＜0.05）;支气管镜检查时间,观察组为（33.6±8.4） min,对照组为（33.1±9.7）min,差异无统计学意义（t=1.348,P＞0.05）.结论 自荧光支气管镜检查对可疑病灶定位准确性高、病理活检阳性率高且减轻活检后出血.

Objective To investigate and analyze the clinical application of auto-fluorescence bronchoscopy（AFB）.Methods 224 patients （M/F =190/34） performed bronchoscopy were selected and randomly divided into the control group （n =112,M/F =96/16） and observation group （n =112,M/F =94/18）.Patients of control group were performed white light bronchoscopy （WLB）.Patients of observation group were performed WLB combined AFB.The primary endpoint was masculine rate of pathology biopsy and bleeding after biopsy.The retrospective analysis was performed.Results The masculine rate of carcinoma in situ of the observation group was 3.1%,which of the control group was 1.0%,the difference was statistically significant（χ^2=19.761,P 〈 0.05）.The masculine rate of atypical hyerplasia of the observation group was 13.2%,that of the control group was 5.5%,the difference was statistically significant（χ^2=21.426,P 〈 0.05）.The category and frequency of arresting bleeding medicine used after biopsy in the observation group was less than the control group,the difference was statistically significant （F =9.574,12.763,all P 〈 0.05）.The time of performed bronchoscopy of the observation group was （33.6 ± 8.4） min,that of the control group was （33.1 ± 9.7） min,the difference was not statistically significant （t =1.348,P 〉 0.05）.Conclusion AFB can improve site-specific accuracy of doubtful focus,improve masculine rate of pathology biopsy,and lessen bleeding after biopsy.