三种药物对脱矿釉质再矿化影响的比较研究

目的比较奥威尔牙齿脱敏剂、多乐氟、碳酸氢钠再矿化液对脱矿釉质再矿化的影响,为临床药物应用提供理论依据。方法选取颌面外科拔除的无龋后牙30颗,制备成4 mm×4 mm的釉质标本60个,随机分为4组(n=15)。可口可乐浸泡脱矿后经奥威尔牙齿脱敏剂(A组)、多乐氟(B组)、碳酸氢钠再矿化液(C组)、去离子水(D组)局部处理7 d,应用原子力显微镜(atomic force microscope,AFM)和扫描电子显微镜(scanning electron microscope,SEM)观察各组釉质标本的表面形态变化及凹陷深度,并测量表面粗糙度和显微硬度。结果 AFM和SEM下可见各组釉质表面呈现不同程度的釉质溶解和再矿化,A组凹陷深度显著小于B、C和D组,差异有统计学意义(P<0.05);A、B组粗糙度显著小于C、D组,差异有统计学意义(P<0.05),A、B组间差异无统计学意义;A组的显微硬度明显高于其他3组,差异有统计学意义(P<0.05)。结论奥威尔牙齿脱敏剂的再矿化效果优于多乐氟和碳酸氢钠再矿化液。

Objective To compare the remineralization effect of Oravie, Duraphat and sodium bicarbonate reminaeralizaiton solution on the decalcified enamel, providing the theoretical foundation for the clinical application of these drugs. Methods 30 molars without caries were chosen from the Dept. of Oral and Maxillofacial Surgery. These teeth were prepared into 60 enamel specimen（4 mm×4 mm） and divided into four groups randomly. They were treated by Oravive （Group A）, Duraphat（Group B）,sodium bicarbonate remineralization solution （Group C） and deionized water （Group D） respectively for seven days after demineralization in Coca Cola. Atomic force microscope （AFM） and scanning election microscope （SEM） were applied to observe the change of the surface morphology and the depth of the pit on the enamel specimen, testing the roughness of the surface and the microhardness.Results Different degree of the solution and remineralization of the enamel surface could be shown under the use of AFM and SEM. The depth of the pit in Group A is significantly smaller than that of Group B,C,and D （P＆lt;0.05）. The roughness of Group A and B is significantly smaller than that of Group C and D but shows no differentiation between Group A and Group B . The microhardness of Group A is significantly higher than the other three groups （P〈0.05）. Conclusion The remineralization effect of Oravive is better than Duraphat and sodium bicarbonate remineralization solution.