糖尿病合并冠心病患者高敏C反应蛋白和血小板参数情况及其临床意义

Clinical Significance of hs CRP and PLT in Diabetes Complicated with CHD

目的:本研究糖尿病合并冠心病患者高敏C反应蛋白和血小板参数情况,并探讨其临床意义。方法:入选2010年6月—2013年12月年就诊于我院的糖尿病合并冠心病患者58例作为观察对象,同期选择入院治疗的冠心病患者58例,糖尿病患者58例及健康体检者29例作为对照对象,观察四组受试对象高敏C反应蛋白和多种血小板参数水平,并对其临床意义进行研究和分析。结果:糖尿病合并冠心病患组患者高敏C反应蛋白、血小板计数(PLT)、平均血小板体积(MPV)、大血小板比率(P-LCR)和血小板分布宽度(PDW)水平显著高于其他三组,差异均具有显著性,P<0.05,说明糖尿病合并冠心病患者高敏C反应蛋白和血小板相关参数均显著高于单纯患有糖尿病或冠心病患者及健康人群。结论:高敏C反应蛋白和各血小板参数对糖尿病合并冠心病的疾病进展有密切的关联,能够作为糖尿病合并冠心病病情发展和治疗疗效评价的有效指标,值得临床推广应用。

Objective： To study the clinical significance of hypersensitive C- reactive protein（ hs CRP） and platelet（ PLT） in complicated with coronary heart disease（ CHD）. Method： 58 diabetes patients complicated with CHD were chosen as research subjects,and in the same period,58 patients with CHD,58 patients with diabetes and 29 healthy persons were chosen as control subjects. hs CRP and PLT of the 4 groups were observed and the relevance among them was studied and analyzed. Result： Levels of hs CRP,PLT,MPV,P- LCR and PDW of diabetes complicated with CHD were obviously higher than those of the other 3 groups（ P〈0.05）,indicating that hs CRP and PLT of diabetes complicated with CHD were both obviously higher than patients with diabetes or CHD only and healthy persons; there was a negative correlation between hs CRP and PLT and a positive correlation among the other indicators. Conclusion： There is an obvious correlation among hs CRP,PLT and progress of diabetes complicated with CHD,and they can be regarded as effective indicators evaluating progress and clinical effect of diabetes complicated with CHD,so this is worth of being popularized clinically.