葡醛内酯片联合合生元益生菌治疗小儿轮状病毒肠炎合并肝损伤的疗效观察

Efficacy observation of glucuronolactone combined with synbiotics probiotics in treatment of rotavirus enteritis with hepatic injury

目的观察并评价葡醛内酯片联合合生元益生菌治疗轮状病毒肠炎合并肝损伤的临床疗效和安全性。方法选取本院60例腹泻患儿,随机均分为对照组和治疗组,每组各30例。治疗组患儿给予葡醛内酯片合并合生元益生菌治疗,同时给予双歧杆菌乳杆菌三联活菌片,对照组患儿给予果糖二磷酸钠及蒙脱石散治疗,比较两组患儿的临床疗效、症状缓解时间及不良反应发生情况。结果 60例中重度腹泻患儿均存在严重的电解质紊乱和不同程度的肝损伤及心肌酶谱变化。治疗组患儿在临床疗效、病程等方面均明显优于对照组(P<0.05),且不良反应轻于对照组。结论采用葡醛内酯片联合合生元益生菌对小儿腹泻的治疗效果优于果糖二磷酸钠与蒙脱石散。

Objective To observe and evaluate the clinical efficacy and safety of glucuronolactone combined with synbiotics probiotics in treatment of rotavirus enteritis with hepatic injury. Method 60 cases with diarrhea in our hospital were chose, randomly divided into control group and treatment group, treatment group were given glucurolactone combined with synbiotics probiotics and triple viable bifidobacterium lactobacillus tablets, control group were given fructose disphosphate sodium and montmorillonite powder. Compared two groups efficacy, remission time and adverse reactions. Result 60 cases all had severe electrolyte imbalance and varying degrees hepatic injury and myocardial enzyme changes. The clinical efficacy and duration in treatment group were better than control group（P〈0.05）, and adverse reaction were lower than control group. Conclusion Glucurolactone piece combined with synbiotics probiotics in treatment of children diarrhea is better than fructose disphosphate sodium and montmorillonite powder.