急性胰腺炎患者血清降钙素原水平变化与临床意义

Serum procalcitonin level in patients with acute pancreatitis and its clinical significance

目的探讨急性胰腺炎患者血清降钙素原(PCT)水平变化与临床意义。方法选取本院2012年2月至2014年2月收治的急性胰腺炎患者150例,按照临床标准将其分为急性轻症胰腺炎组和急性重症胰腺炎组,每组各75例。两组患者治疗前血清PCT水平与正常值[(0.55±0.21)μg/L]进行比较,比较两组患者治疗前后血清PCT水平。结果两组患者治疗前血清PCT水平均显著高于正常值(P<0.01),组间比较差异具有显著性(t=12.4611,P<0.05);治疗1、3、7天后,急性轻症胰腺炎组患者PCT水平明显低于急性重症胰腺炎组,差异具有显著性(t=53.1159,P<0.01;t=61.7751,P<0.01;t=92.1915,P<0.01)。随治疗时间的延长,急性轻症胰腺炎组患者血清PCT水平逐渐降低,而急性重症胰腺炎组患者血清PCT水平一直较高,且呈逐渐升高的趋势。结论血清PCT水平反映急性胰腺炎的病情程度,可用于早期判断患者是否感染,有利于急性胰腺炎的早期预防及治疗,方法简单,准确度较高,值得临床推广应用。

Objective To investigate serum procalcitonin（PCT） level in patients with acute pancreatitis and its clinical significance. Method 150 patients with acute pancreatitis were selected from February 2012 to February 2014 in our hospital. According to clinical criteria, 150 patients were divided into acute mild pancreatitis group and severe acute pancreatitis group, 75 cases in each group. Compared the serum PCT level of two groups before and after treatment. Result Before treatment, the PCT levels of two groups of patients were significantly higher than normal level（P〈0.01）. Before treatment, the PCT levels of two groups of patients had significant difference（t = 12.4611, P〈0.05）. After 1, 3, 7 days acute, the PCT levels of patients in severe pancreatitis group were significantly higher than those mild acute pancreatitis group（t = 53.1159, P〈0.01; t =61.7751, P〈0.01; t = 92.1915, P〈0.01）. With the extension of treatment time, the dynamic changes of PCT levels in two groups of patients was different, after treatment, PCT levels were decreased gradually of mild acute pancreatitis group patients, and severe acute pancreatitis group of patients with PCT levels were higher, and had the trend of gradually increasing. Conclusion Serum procalcitonin can reflect the severity of acute pancreatitis, it can be used to determine whether patients had the early infection, it is helpful for the early prevention and treatment of acute pancreatitis, this value is simple and accurate. It is worth popularizing in clinic.