虫草对肺部疾病治疗的研究进展

A Review of Cordyceps in Treatment of Lung Diseases

肺纤维化、慢性阻塞性肺病和哮喘是人类主要的呼吸系统疾病,它们均以肺部或呼吸道的慢性炎症为特征,当前的治疗方法尚不理想并伴随着很多的副作用,人们迫切需要一种更安全的替代疗法。冬虫夏草是我国传统的名贵药用真菌,被广泛用来治疗多种肺部疾病。近年来,冬虫夏草对肺部疾病治疗作用的研究取得了较大进展,本文综述了冬虫夏草、其无性型中国被毛孢(Hirsutella sinensis或Ophicordyceps sinensis)和其他相关虫草及其提取物对肺纤维化、慢性阻塞性肺病、哮喘等肺部疾病治疗作用的研究进展,并介绍了其作用机制的研究成果。

Lung fibrosis, COPD and Asthma are the principal respiratory diseases. They are all characterized by chronic inflammation of the Lung or airway. The current therapies are inadequate and have numerous adverse effects. There is an acute need of potential alternative therapies. Cordyceps sinensis is one of the most valuable Chinese herbal medicines. It is widely used for treating various lung disease. In recent few years, understanding of Cordyceps sinensis in treating lung diseases has made much progress. This paper summerized the advances of Cordyceps sinensis and its anamorph Hirsutella sinensis, and other correlated species and their extracts for lung fibrosis, COPD and Asthma treatment, and reviewed the mechanisms. ZHANG Ying-zhuo1, YANG Xiao-ton~~, YANG Qing-yao2, FENG Hui-qin~, YANG Ming-junt （1 Institute of Microbiology d~ Immunology, Shanghai Normal University, Shanghai, 200234, China; 2 Shanghai Yang＇s Herb Institute Shanghai, 200234, China）