微波射频保肢术及截肢术治疗胫骨远端骨肉瘤的临床疗效比较

Comparison of the Clinical Efficacy of Limb Salvage with Microwave Hyperthermia and Amputation in the Treatment of Distal Tibia Osteosarcoma

目的:探讨和比较截肢术和微波射频保肢术治疗胫骨远端骨肉瘤的临床效果和安全性。方法:选择2000年-2013年我院收治的明确诊断为胫骨远端骨肉瘤的患者79例,其中27例给予截肢治疗(截肢组),52例给予微波射频保肢和重建治疗(保守治疗组)。评价和比较两组患者的生存情况、局部复发情况、MSTS关节功能评分及并发症的发生情况。结果:两组患者的生存曲线、局部复发率和并发症的发生率比较均无统计学差异(P>0.05),但保守治疗组的MSTS关节功能评分显著高于截肢组,差异有统计学意义(P<0.05)。结论:微波射频保肢术治疗胫骨远端骨肉瘤患者不会降低患者的生存几率,且在改善患者的关节功能方面有明显的优势。

Objective： To compare the clinical effect and safety between patients with distal tibia osteosarcoma treated by limb salvage with microwave hyperthermia and amputation. Methods： 79 patients who were admitted in our hospital from 2000 to 2013 and diagnosed as distal tibia osteosarcoma were selected, in which 27 patients were treated by amputation and 52 patients were given limb salvage and allograft reconstructions. The survival situation, local recurrence, MSTS score of joint function as weill as incidence of complications were evaluated and compared between the two groups. Results： No significant difference was found in the survival curve,local recurrent rate and incidence of complications between the two groups（P〉0.05）, but the MSTS score of joint function of patients treated by limb salvage and allograft reconstruction was predominantly higher than that of patients treated by amputation（P〈0.05）.Conclusion： Limb salvage using microwave hyperthermia wouldn＇t reduce the chances of survival of patients with distal tibia osteosarcoma, and had the advantage of improving patients＇ joint function.