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丙型肝炎病毒相关正向和负向T细胞免疫应答的研究进展 被引量：2

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摘要 据世界卫生组织统计,自1989年发现丙型肝炎病毒（HCV）以来,全球已有约3%的人感染了HCV,其中少数在急性感染期即可自发清除病毒,而多数约170 000 000的感染者最终会发展成慢性肝炎。HCV是终末期肾病最主要的诱因之一,大多数慢性携带者会逐渐经历肝纤维化、肝硬化、甚至肝细胞癌的过程。
作者 陆冰云 李婷婷
机构地区 南方医科大学第一临床医学院 南方医科大学生物技术学院
出处 《广东医学》 CAS CSCD 北大核心 2014年第20期3265-3267,共3页 Guangdong Medical Journal
基金 南方医科大学"科研启动计划"青年科技人员培育项目(编号:PY2013N023)
关键词 丙型肝炎病毒 T细胞免疫应答 急性感染期 世界卫生组织 终末期肾病 慢性携带者 慢性肝炎 肝纤维化
分类号 R512.63 [医药卫生—内科学]
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参考文献30

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同被引文献27

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  • 3Wahle RC, Perez RM, Pereira PF, et al. Hepatitis B virus reacti- vation after treatment for hepatitis C in hemodialysis patients with HBV/HCV coinfection [J]. Braz J Infect Dis, 2015,19(5) :533- 537.
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  • 5Fernandez-Ponce C, Dominguez-Villar M, Aguado E, et al. CD4 + primary T cells expressing HCV-core protein upregulate foxp3 and IL-10, suppressing CD4 and CD8 T cells [J]. PLoS One, 2014,9( 1 ) :e85191.
  • 6Yue M, Deng X, Zhai X, et al. Thl and Th2 cytokine profiles in- duced by hepatitis C virus F protein in peripheral blood mononu- clear cells from chronic hepatitis C patients [ J ]. Immunol Lett, 2013,152(2) :89-95.
  • 7Mohamadkhani A, Katoonizadeh A, Poustehi H, et al. Immune- regulatory events in the clearance of HBsAg in chronic hepatitis B : focuses on HLA-DP [J]. Middle East J Dig Dis, 2015,7( 1 ) :5- 13.
  • 8MeLaughlin KA, Gulati K, Richardson CC, et al. HLA-DR4-as- soeiated T and B cell responses to specific determinants on the IA- 2 autoantigen in type 1 diabetes [J]. J Imnmnol, 2014,193(9) : 4448-4456.
  • 9Duquesnoy R J, Marrari M, Tambur AR, et al. First report on the antibody verification of HLA-DR, HLA-DQ and HLA-DP epitopes recorded in the HLA Epitope Registry [J]. Hum Immunol, 2014, 75 ( 11 ) : 1097-1103.
  • 10Huang P, Zhang Y, Lu X, et al. Association of polymorphisms in HLA antigen presentation related genes with the outcomes of HCV infection [J]. PLoS One, 2015,10(4) : e0123513.

引证文献2

二级引证文献7

广东医学
2014年 第20期

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