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宿主细胞DNA损伤反应与重组腺相关病毒载体基因表达 被引量：1

Interplay between DNA-Damage Response and Recombinant Adeno-Associated Virus Vector in Host Cells
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摘要 文中主要讨论细胞DNA修复机制与重组腺相关病毒(recombinant adeno-associated virus,rAAV)载体的相互关系,探讨通过调节宿主细胞DNA修复机制,提高rAAV载体表达及基因打靶效率的方法,进而提高rAAV载体基因表达的可能性. The article mainly discusses the connection between the mechanism of DNA repair in cells and the recombinant AAV（rAAV）vectors,and explores the methods for improving the efficiency of rAAV vectors expression and gene targeting by regulating the mechanism of DNA repair in host cells,thus more likely to increase the rAAV vectors gene expression.
作者 彭俊纯 刁勇 李招发 王启钊 吕颖慧
机构地区 华侨大学生物医学学院
出处 《华侨大学学报（自然科学版）》 CAS 北大核心 2014年第5期564-569,共6页 Journal of Huaqiao University(Natural Science)
基金 国家国际科技合作专项项目(2011DFG33320) 国家自然科学基金资助项目(81371669 81271691 81201183) 福建省自然科学基金资助项目(2012J01397)
关键词 腺相关病毒 基因治疗 DNA损伤修复 基因打靶 adeno-associated virus gene therapy DNA damage repair gene targeting
分类号 Q78 [生物学—分子生物学]
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参考文献51

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二级参考文献61

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华侨大学学报（自然科学版）
2014年 第5期

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