芍药甘草汤合补阳还五汤联合乙哌立松治疗中风后肌张力增高疗效观察

Therapeutic Effect of Shaoyao Gancao Decoction and Buyang Huanwu Decoction Combined with Eperisone for Muscular Hypertonia After Stroke

目的:观察芍药甘草汤合补阳还五汤加减联合乙哌立松治疗气虚血瘀型中风后肌张力增高临床疗效。方法:将150例纳入病例随机分为3组,每组50例,3组均给予常规治疗。A组加乙哌立松口服、汤药予补阳还五汤加减。B组给予芍药甘草汤合补阳还五汤加减。C组给予乙哌立松口服,汤药以芍药甘草汤合补阳还五汤加减。疗程均为1月。结果:A组总有效率为70%,B组为68%,C组为88%,C组明显优于A、B组,差异有显著性意义(P<0.05)。各组Fugl-Meyer(FMA)评分治疗前后比较,差异均有显著性意义(P<0.05)。治疗后各组FMA评分比较,差异均有显著性意义(P<0.05);C组评分明显优于A、B组,差异有显著性意义(P<0.05)。各组Barthel指数治疗前后比较,差异均有显著性意义(P<0.05)。治疗后各组Barthel指数比较,差异均有显著性意义(P<0.05);C组指数明显优于A、B组,差异有显著性意义(P<0.05)。各组中医证候评分治疗前后比较,差异均有显著性意义(P<0.05)。治疗后各组中医证候评分比较,差异无显著性意义(P>0.05)。结论:以芍药甘草汤合补阳还五汤联合西药肌松药治疗肌张力升高、属气虚血瘀型的中风患者,可较显著地降低患肢肌张力、改善患肢运动功能,疗效确切。

Objective： To observe the clinical effect of Shaoyao Gancao decoction and Buyang Huanwu decoction combined with eperisone for muscular hypertonia after stroke. Methods： One hundred and fifty cases were randomly divided into three groups. All of the three groups were given conventional treatments. Additionally, group A with 50 cases was treated with Buyang Huanwu decoction combined with eperisone orally, group B with 50 cases was treated with Shaoyao Gancao decoction and Buyang Huanwu decoction, and group C with 50 cases was treated with Shaoyao Gancao decoction and Buyang Huanwu decoction combined with eperisone. The treatment course lasted for one month. Results： The total effective rate was 70% in group A, 68% in group B and 88% in group C, the clinical effect of group C being superior to that of group B or group A（P〈 0.05）. After treatment, FugeI-Meyer scores（FMA）, Barthel index（BI） and the scores of Chinese medical（CM）syndrome of all groups were improved（P〈 0.05 compared with those before treatment）. FMA and BI of group C were statistically superior to those of group A and group B. The differences of CM syndrome scores were insignificant among the three groups（P〉0.05）. Conclusion： Shaoyao Gancao decoction and Buyang Huanwu decoction combined with eperisone have certain effect for the treatment of post-stroke muscular hypertonia patients with the syndrome of qi deficiency and blood stasis through relieving muscular tension and improving motor function of the affected limbs.