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脑胶质瘤患者LMO-1和LMO-4基因表达水平的改变及其意义 被引量：2

Expression and Significance of LMO-1 and LMO-4 in Human Glioma
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摘要 目的探讨脑胶质瘤患者脑组织中LMO-1和LMO-4基因表达水平的改变及其意义。方法采用实时荧光定量聚合酶链反应(real-time PCR)检测46例脑胶质瘤手术患者脑组织及19例正常脑组织标本中LMO1和LMO4的表达水平,分析LMO1、LMO4与病理分级之间的关系。结果脑胶质瘤患者脑组织中LMO-1表达高于正常对照组(P<0.05);LMO1在不同分级的胶质瘤中表达并不相同,在Ⅲ、Ⅳ级中的相对表达量显著高于Ⅰ、Ⅱ级(P<0.01);LMO1表达水平与胶质瘤分级正相关,差异具有显著性意义(P<0.05)。在多形性胶质母细胞瘤患者脑组织中,LMO-4的表达明显高于其它级别胶质瘤和正常对照组(P<0.05)。结论脑胶质瘤患者肿瘤组织中LMO-1和LMO-4表达增高,可能参与了胶质瘤的发生、发展过程。 Objective To investigate the expression of LMO-1 and LMO-4 in human glioma and normal brain tissues and evaluate their clinical significance. Methods The levels of LMO-1 and LMO-4 in brain specimens collected from 46 patients with gliomas and 19 normal controls were measured by quantitative real-time PCR. The relationship between these expressions and pathological grade were also analyzed. Results LMO-1 expression in brain specimens of glioma patients was statistically higher than that in the controls. Compared with that in low- grade gliomas, the levels of LMO- 1 in high- grade gliomas were significantly increased. There was a positive correlation between LMO-1 expression level and the pathological grade of gliomas. LMO-4 mRNA levels were higher in glioblastoma multiform than the well-differentiated glioma and normal brain tissues. Conclusion The expression of LMO-1 and LMO-4 are elevated in glioma patients. They may participate in the occurrence and development of glioma.
作者 董成亚 李昊文 刘丽 康熙雄 王雅杰
机构地区 首都医科大学附属北京天坛医院临床医学研究实验室 首都医科大学附属北京天坛医院检验科
出处 《标记免疫分析与临床》 CAS 2014年第5期568-570,580,共4页 Labeled Immunoassays and Clinical Medicine
基金 首都医科大学附属北京天坛医院青年科研基金(2013年度) 脑肿瘤北京市重点实验室2014年开放课题(2014NZLY01) 北京市自然科学基金(7132094) 北京市卫生系统高层次卫生技术人才队伍建设专项经费(2011-3-038)
关键词 脑胶质瘤 LMO-1 LMO-4 表达 Glioma LMO- 1 LMO-4 Expression
分类号 R739.4 [医药卫生—肿瘤]
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参考文献12

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同被引文献16

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标记免疫分析与临床
2014年 第5期

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