上海地区多个肿瘤标志物正常参考值的初步确定

Establishment of the Reference Range of Multi-Tumor Markers for Healthy People in Shanghai

目的通过回顾分析初步建立上海地区健康人群多个肿瘤标志物的参考区间,可为临床应用肿瘤标志物提供依据。方法选择2012年3月至2013年4月期间在复旦大学附属华山医院进行健康体检样本共计604例,采用流式荧光发光法检测血清中甲胎蛋白(AFP)、糖类抗原125(CA125)、细胞角蛋白19片段(CYFRA21-1)癌胚抗原(CEA)、神经元烯醇化酶(NSE)、糖类抗原19-9(CA19-9)、总前列腺特异性抗原(tPSA)浓度值,对浓度值做统计分析。结果 AFP参考值:男性<10.32ng/mL,女性<8.12ng/mL;CA125参考值:<27.02U/mL;CEA参考值:男性<4.3ng/mL,女性<3.74ng/mL;NSE参考值:女性青年组(<45岁)<11.64ng/mL,女性中老年组(≥45岁)<15.20ng/mL,男性青年组(<45岁)<18.47ng/mL,男性中老年组(45岁)<20.04ng/mL;CA199参考值:<20.73U/mL;tPSA参考值:<1.48ng/mL。结论已经初步建立上海地区各个肿瘤标志物参考区间。

Objective To establish the normal reference range of serum tumor markets for health people in Shanghai to provide the basis for the clinical application. Methods 604 healthy human serum which were collected from March 2012 to April 2013 have been tested by Flow Fluorescence Immunoassay for the concentration of AFP, CA125, CYFRA21-1, CEA, NSE, and CA19-9. Results The AFP reference range was 〈 10.32ng/mL in male and 〈 8.12ng/mLin female; CA125 reference range was 27.02U/mL; CEA reference range was 〈 4.3ng/mL in male and 〈 3.74ng/mLin female; NSE reference range was 〈 11.64ng/mL in female with age less than 45years, 〈 15.20ng/mL in female with age more than 45years, 〈 18.47ng/mL in male wit age less than 45years and 〈 20.04ng/mL with age more than 45 years ; CA19-9 reference range was 〈 20.73U/mL; and tPSA reference range was 〈 1.48ng/mL. Conclusion The preliminarily reference range of AFP, CA125, CYFRA21-1, CEA, NSE, CA19-9 for healthy people in Shanghai are established.