术前预防性使用抗生素对剖宫产切口感染的影响

Effect of Using Antibiotics Preventatively Before Operation on Wound Infection in Caesarean Section

目的探讨术前预防性使用抗生素对剖宫产术后切口感染的影响。方法以2012年1月至2014年1月间我院收治的106例剖宫产孕妇为研究对象,随机分为术前应用抗生素组(观察组)及术后应用抗生素组(对照组)各53例。比较两组患者术中出血量、术后体温及血液学检查结果,观察患者术后感染情况。结果观察组术中出血量为165.4 mL,对照组为159.2 mL,两组之间差异无统计学意义(P>0.05);观察组甲级愈合率为96.2%,对照组甲级愈合率为90.6%,两组之间差异有统计学意义(P<0.05);观察组术后最高体温>38℃者4例、对照组术后最高体温>38℃者7例,两组之间差异无统计学意义(P>0.05);观察组C反应蛋白异常升高者2例,对照组术后C反应蛋白异常升高者9例,两组之间差异有统计学意义(P<0.05);观察组术后腹部切口感染、产褥感染例数分别为1例和1例,对照组术后腹部切口感染、产褥感染例数分别为5例和3例,两组之间差异有统计学意义(P<0.05);两组术后各有1例泌尿系统感染病例,差异无统计学意义(P>0.05)。结论术前预防性使用抗生素降低患者术后切口感染的发生,有利于切口愈合。

Objective To investigate the effect of preoperative antibiotics on wound infection in caesarean section. Methods 106 cases of patients with cesarean section treated in our hospital from January 2012 to January 2014 were selected as objects and randomly divided into preoperative antibiotic group （observation group） and postoperative antibiotic group （control group）, 53 cases per group. The bleeding volume, postoperative body temperature and hematological examinations and postoperative infection of two groups were observed and compared. Results The bleeding volume of the observation group was 164.5 mL, the bleeding volume of the control group was 159.2 mL, without statistically significant difference （P 〉0.05）; the first healing rate of observation group was 96.2%, significantly higher than 90.6% of the control group, with statistically significant difference （P 〈0.05）; the highest temperature after operation 〉38 ℃ of the observation group was 4 cases, the highest temperature after operation 〉38 ℃ of the control group was 7 cases, without statistically significant difference （P〉0.05）;the abnormal rise of C-reactive protein of the observation group was 2 cases, significantly lower than 9 cases of the control group, with statistically significant difference （P 〈0.05）; the abdominal incision infection and puerperal infection of the observation group were 1 case and 1 cases respectively, significantly lower than 5 cases, 3 cases of the control group respectively, with statistically significant difference （P 〈0.05）; there were 1 case of postoperative urinary tract infection in each group, without statistically significant difference （P 〉0.05）. Conclusions The preventative application of antibiotics before operation can reduce the incidence of postoperative wound infection, which is helpful to wound healing.