慢性阻塞性肺疾病患者血浆醛固酮的表达特征

Characterristics of plasma aldosterone in patients with chronic obstructive pulmonary

目的探讨慢性阻塞性肺疾病(COPD)患者血浆醛固酮的表达特征。方法根据肺功能损害程度将90例COPD患者分为轻中度组(36例)及重度极重度组(54例);再根据病情将COPD患者分为单纯COPD组(33例),肺心病组(57例),同时和29例健康者采用放射免疫分析法进行醛固酮水平的检测,并进行肺功能检查及血气分析检测。结果肺心病组患者醛固酮水平显著高于单纯COPD组及对照组(P<0.05);重度极重度COPD组的醛固酮较轻中度组升高(P<0.05);血浆醛固酮与动脉血氧分压呈负相关(r=-0.460,P=0.00)。结论醛固酮在COPD患者中有异常表达,与肺心病存在一定的相关性。

Objective To investigate the characterristics of plasma aldosterone in patients with chronic obstructive pulmonary. Methods 90 patients with COPD were divided into mild and moderate group（ 36 cases）,severe and extremely severe group（ 54 cases） according to the lung function damage,then 90 patients were also divided into Pure COPD group（ 33 cases） and pulmonary heart disease group（ 57cases） depending acuteness of the disease. Radioimmunoassay method was used to detected the levels of aldosterone in 90 samples of COPD（ COPD group） and 29 samples of healthy people（ control group）,all of the subjects above were monitored for pulmonary function tests and blood gas analysis. Results The level of plasma aldosteron in COPD group was significantly higher than that in control group（ P〈0. 05）,the level of plasma aldosteron in severe and extremely severe group was higher than that in mild and moderate group（ P〈0. 05）; the level of plasma aldosteron was negatively related to PaO2（ r =-0.460,P =0.00）. Conclusions The expression of plasma aldosteron in patients with chronic obstructive pulmonary disease is abnormally,there is some correlation between plasma aldosteron and chronic corpulmonale.