常规疗法联用盐酸帕罗西汀治疗功能性消化不良的疗效观察

Therapeutic effect of the conventional therapy plus paroxetine on the functional dyspepsia

目的评价常规疗法联合应用盐酸帕罗西汀治疗功能性消化不良(FD)的疗效。方法将93例FD患者随机分为两组,对照组患者用常规方法治疗,治疗组患者在常规治疗方法基础上加用盐酸帕罗西汀治疗,20 mg/次,1次/d,疗程6周,比较两组患者的临床治疗效果。结果治疗组患者治疗总有效率(95.7%)显著高于对照组患者(76.1%),治疗组患者临床疗效显著优于对照组患者,差异有统计学意义(P<0.01)。治疗组患者复发率(12.8%)显著低于对照组患者(30.4%),差异有统计学意义(P<0.05)。结论在常规治疗方法基础上联用盐酸帕罗西汀治疗功能性消化不良疗效显著、安全性高,值得临床推广应用。

Objective To study the therapeutic effect of the conventional therapy plus paroxetine on functional dyspepsia.Methods 97 patients with functional dyspepsia were randomly divided into control group（ n = 46） and observation group（ n = 47）,the control group were given conventional treatment,while the observation group were received paroxetine（ 20 mg,orally,once a day） based on conventional treatment,the course of treatment was 6 weeks. The therapeutic effect of the two groups were compared.Results Total effective rate of observation group and control group was 95. 74% and 76. 09%,respectively,and the therapeutic effect of observation group was superior to control group. The reoccurrence rate of the observation group（ 12. 8%） was lower than that in the control group（ 30. 4%）,there was significant difference between two groups（ P〈0. 01）. Conclusions Conventional therapy plus paroxetine in treatment of functional dyspepsia was safety and can improve the therapeutic effect,which is worthy of clinical promotion and application.