胰岛素抵抗检测的原理及研究技术进展

Principle of insulin resistance assessment and the advancement in techniques for investigation

胰岛素抵抗是一种常见症状。它作为代谢综合征主要进展因素之一,有较多检测方法。且逐渐凸显的重要性使得其检测谱从其受体、信号通路、细胞和分子水平均有涵盖。其中正糖钳夹技术和频取样静脉葡萄糖耐量试验最为可靠,而从单一样本获取的指标更适合于大规模人群研究。胰岛素样生长因子等可用于临床检测。当进行一项研究时,需罗列出这些方法的优劣点进行考虑。此外,这篇综述还呈现了获取更多胰岛素抵抗信息的补充方法。

Insulin resistance（ IR） is a common condition. As one of the major aggravating factors for metabolic syndrome,there are many methods for assessment of IR. The emerging importance of IR has led to wider research studies that have examined its receptors, signaling pathway, cellular and molecular mechanism. Ranging from complex techniques down to simple indices,the hyperinsulinaemic euglycaemic clamp and its alternative the frequently sampled intravenous glucose tolerance test are the most reliable ones.However,indices derived from one-off fasting specimens lend themselves for use in large population studies.While relatively simple markers is required for clinical situations,insulin-like growth factor binding protein-1 may be helpful. Providing limitations and advancements which must be considered before proceeding with a study,this review also presents further information on insulin resistance obtained using the complementary techniques.