2型糖尿病患者中亚临床甲状腺功能减退症与糖尿病微血管病变相关性研究

The correlation between the subclinical hypothyroidism and diabetic microvascular complication in type 2 diabetic patients

目的探讨2型糖尿病患者中亚临床甲状腺功能减退症与糖尿病微血管病变的关系。方法选取太原市人民医院内分泌科住院的2型糖尿病患者312例,根据是否合并亚临床甲状腺功能减退症分为亚临床甲状腺功能减退症组和单纯糖尿病组,对比分析2组患者临床指标和微血管并发症状况。结果 2型糖尿病合并亚临床甲状腺功能减退症组女性所占比例(70.0%)明显高于单纯糖尿病组(52.6%),病程(11.3±8.1)年显著长于单纯糖尿病组(9.5±7.0)年,甘油三酯(2.1±1.5)mmol/L及胆固醇(5.3±1.1)mmol/L水平高于单纯糖尿病组(1.4±1.1)mmol/L,(4.8±0.9)mmol/L,差异有统计学意义(P<0.05)。合并亚临床甲状腺功能减退症患者糖尿病肾病发生率65%,均高于单纯糖尿病组44%,差异有统计学意义(P<0.05)。结论亚临床甲状腺功能减退症是糖尿病肾病的独立危险因素。

Objective To investigate the relation between the subclinical hypothyroidism and diabetic microvascular complication in type 2diabetic patients.Methods Three hundred and twelve cases of diabetes treated by endocrine department of the People′s Hospital of Taiyuan City were divided into combined with subclinical hypothyroidism group and the diabetes alone group accordingly.The clinical features and microvascular complication of the two groups were compared.Results The female proportion（70.0%）,course of the disease（11.3±8.1）year,total cholesterol（5.3±1.1）mmol/L and triglyceride levels（2.1±1.5）mmol/L in type 2diabetes combined with subclinical hypothyroidism were significantly higher than those of the diabetes alone group（52.6%）;（9.5±7.0）year;（4.8±0.9）mmol/L;（1.4±1.1）mmol/L（P〈0.05）.The incidence of diabetic nephropathy in combined subclinical hypothyroidism patients were 65%,higher than that of the diabetes alone group（44%）,the difference was statistically significant（P0.05）.Conclusion Subclinical hypothyroidism was an independent risk factor for diabetic nephropathy.