摘要
目的探讨双歧三联活菌胶囊对溃疡性结肠炎(UC)患者血清白介素(IL)-1β、10和肿瘤坏死因子(TNF)-α水平的影响及疗效观察。方法选取UC患者76例随机分为观察组和对照组。两组患者均予以常规治疗(根据病情轻重选用抗生素、5-氨基水杨酸、糖皮质激素等治疗)。观察组患者在此基础上加用口服双歧三联活菌胶囊420mg/次,3次/d,连用8周。观察两组患者治疗前后血清IL-1β、10和TNF-α水平变化,并比较其临床疗效。结果治疗8周后,两组患者血清IL-1β和TNF-α水平明显下降,IL-10水平明显上升(P<0.05或P<0.01),且观察组下降值或上升值较对照组更明显(P<0.05);同时观察组患者临床总有效率明显高于对照组(94.74%vs 78.95%)(χ2=4.15,P<0.05)。结论双歧三联活菌胶囊治疗UC具有良好的临床效果,作用机制与其能降低血清IL-1β和TNF-α水平,提高血清IL-10水平,通过纠正促炎症因子与抗炎症因子的比例失衡,减轻肠道黏膜局部炎症反应密切相关。
Objective To discuss the influence and curative effect of Bifid Triple Viable Capsules on serum Interleukin-1β and 10(IL-1β and 10) and tumor necrosis factor-α( TNF-α) levels of patients with ulcerative colitis(UC). Methods 76 patients with UC were divided into observation group and control group at random. Both groups were given routine medical treatments including antibiotics,5-aminosalicylic acid(5-ASA),GCS etc as appropriate. The patients in observation group were additionally given 420 mg of oral Bifid Triple Viable Capsules t.i. d. for 8 weeks. The changes of serum IL-1β and 10 and TNF-α levels of patients in both groups after medical treatment were observed,and the clinical curative effect was compared as well. Results After 8 weeks' medical treatment,the serum IL-1β and TNF-α levels of patients in both groups obviously declined,while the IL-10 levels obviously rose(P 0. 05 or P 0. 01),with the declining or rising rates of patients in observation group much higher than those in control group( P 0. 05). Meanwhile,the total clinical efficiency of patients in observation group was much higher than that in control group(94. 74% vs 78. 95%)(χ^2= 4. 15,P 0. 05). Conclusion Bifid Triple Viable Capsules has favorable curative effect on UC,the mechanism of which is closely associated with its effect of reducing serum IL-1β and TNF-α levels,rising serum IL-10 level,and reducing the local inflammatory reaction of intestinal mucosa by adjusting the imbalance of proinflammatory cytokines and inflammation cytokines.
出处
《中国微生态学杂志》
CAS
CSCD
2014年第8期914-916,共3页
Chinese Journal of Microecology