利奈唑胺对老年患者血液系统的影响

The effects on hematological system among elderly patient caused by linezolid

目的探讨利奈唑胺对老年患者血液系统产生的不良影响,为合理用药和提高老年患者用药安全性提供参考。方法回顾性分析2011~2012年在住院期间曾使用利奈唑胺抗感染治疗的老年患者血液系统异常的发生率及特点。结果使用利奈唑胺后15.6%患者白细胞降低至正常值以下,但停药后多数可恢复。42.2%患者发生血红蛋白下降,其中不到半数患者停药后可恢复至治疗前水平,且需时间较长。78.1%患者出现血小板降低,其中42.2%降低至正常值以下,25%降至50×10^9/L以下,大多数患者停药2周后血小板可恢复至治疗前水平。结论老年患者使用利奈唑胺后血液系统不良反应的发生率和严重程度高于其他人群,故老年患者使用利奈唑胺过程中需密切监测血常规。

Objective To investigate the adverse effects on hematological system among elderly patient caused by linezolid. Methods The clinical data of 64 elderly patients who were treated with linezolid between 2011 ~ 2012 when hospitalized in our department were analyzed retrospectively. Results Leukocytopenia occurred in 15. 6 percent of patients,but normalized soon after drug withdrawal in most of them. Decrease of hemoglobin occurred in 42. 2 percent of patients,and less than half of them could return to the baseline. The incidence of thrombocytopenia was42. 2%,and the platelet count of 16（ 25%） patients decreased below 50 × 10^9/L. But the platelet count of most patients would return to the baseline at two weeks after drug withdrawal. Conclusion The incidence and the severity of adverse reactions to hematological system caused by linezolid in elderly patient were higher than that in general population. Complete blood count should be monitored carefully in elderly patients who are treated with linezolid.