中西医结合治疗对急性缺血性中风阴类证患者神经功能及hs-CRP、TNF-α、IL-6的影响研究

Research of influence of integrative medical therapy on neurological function and concentration levels of hs-CRP,TNF-α,IL-6 in patients with Yin syndrome type acute ischemic stroke

目的探讨中西医结合治疗对急性缺血性中风阴类证患者神经功能及高敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)浓度的影响。方法将100例缺血性中风阴类证住院患者随机分为治疗组和对照组各50例。2组患者均给予基础治疗及康复治疗,在此基础上治疗组给予益气活血、醒脑涤痰中药汤剂口服及丹红注射液静脉点滴,对照组给予低分子右旋糖苷、胞磷胆碱静脉点滴。2组患者分别于治疗前、治疗第14天采用美国国立卫生研究院卒中量表(NIHSS)评价神经功能并测定hs-CRP、TNF-α、IL-6浓度。结果治疗后2组患者hs-CRP、TNF-α、IL-6浓度及NIHSS评分均较同组治疗前显著下降(P均<0.05),且治疗组下降程度更明显(P均<0.05)。结论中西医结合治疗方案能改善急性缺血性中风阴类证患者治疗前后神经功能,降低hs-CRP、TNF-α、IL-6浓度。

Objective It is to explore the influence of integrative medical therapy on neurological function and concentrations of hs- CRP,TNF- α,IL- 6 in patients suffering from Yin syndrome type acute ischemic stroke. Methods One hundred patients suffering from Yin syndrome type acute ischemic stroke were randomly divided into the treatment group and control group,each group had 50 cases. Both the groups were given basic treatment and rehabilitation. Meanwhile,the treatment group was given Chinese decoction with the effects of supplementing Qi and activating blood circulation,restoring consciousness and clearing phlegm by oral administration and Danhong injection by IV drip. The control group were given citicoline,low molecular weight dextran by IV drip. The scores of NIHSS were assessed,and the concentration of hs- CRP,TNF- α,IL-6 were determined after admission and 14 days＇ treatment. Results After treatment,the concentrations of hs- CRP,TNF- α,IL- 6 and NIHSS scores were significantly lower than those before treatment in both groups（ P〈0.05）. However,the concentration of those in treatment group were significantly lower than that in control group（ P all 〈0. 05）. Conclusion The integrative medical therapy can significantly improve neurological function,decrease the concentration level of hs- CRP,TNF- α,IL- 6and NIHSS scores in patients suffering from Yin syndrome type acute ischemic stroke.