河南省2012年育龄期妇女乙肝血清学调查及风险因素分析

A serological survey of hepatitis B virus and risk factors among women of child-bearing age in Henan Province,2012

目的了解河南省现阶段育龄期妇女乙型病毒性肝炎（乙肝）病毒表面抗原[hepatitis B virus（HBV）surface antigen,HBsAg]、抗乙肝病毒表面抗原抗体（antibody to HBsAg,anti-HBs）、乙肝病毒e抗原（HBV e antigen,HBeAg）、抗乙肝病毒e抗原抗体（antibody to HBeAg,anti-HBe）的流行情况。方法用血清流行病学分析方法,在河南省多阶段随机抽取15~49岁常住人口,采集调查对象静脉血5 ml,统一检测HBsAg、抗-HBs。HBsAg阳性者再进一步检测HBeAg和抗HBe;对15~49岁育龄期妇女进行HBsAg及HBeAg流行状况分析。结果河南省育龄期妇女HBsAg流行率为3.77%,抗-HBs流行率为28.53%。在HBsAg阳性育龄期妇女中,HBeAg流行率为24.58%,抗HBe流行率为73.65%。育龄期妇女HBsAg流行率在城乡和文化程度之间的差异均有统计学意义（均有P〈0.05）。结论河南省现阶段,育龄期妇女HBsAg流行率低于河南省一般水平。

Objective To get the prevalence of hepatitis B virus（ HBV） surface antigen（ HBsAg）,antibody to HBsAg（ anti-HBs）,HBV e antigen（ HBeAg） and antibody to HBeAg（ anti-HBe） of the child-bearing women in Henan. Methods Participants aged from 15 to 49 years were selected by multiple-stage sampling randomly from Henan and 4ml blood were drawn from each participant. The data of child-bearing women with 15-49 years of age were collected,HBsAg,antiHBs and anti-HBc were detected by ELISA. The HBsAg positive sample were also detected for HBeAg and HBeAb. Results The adjusted prevalence of HBsAg and anti-HBs were 3. 77% and 28. 53%,respectively. Among the HBsAg positive women,the adjusted prevalence of HBeAg and anti-HBe were 24. 58% and 73. 65%,respectively. There were significant differences in HBsAg prevalence between city and rural,nationality and education. Conclusions In Henan,the prevalence of HBsAg was 3. 77% in child-bearing women,which is lower than that in the whole population in Henan.