血清降钙素原在医院内获得性肺炎疗效评估中的价值分析

Evaluation and Analysis on Efficacy of Serum Procalcitonin in Hospital-acquired Pneumonia

目的分析血清降钙素原(PCT)在评估医院内获得性肺炎治疗效果中的价值。方法回顾性分析对我院2011年1月—2014年1月住院部收治的168例医院获得性肺炎患者,根据是否动态检测PCT分为观察组与对照组。观察组患者根据血清降钙素原的监测结果进行抗菌治疗,对照组给予常规的抗感染治疗;分析比较两组患者的临床疗效,包括抗生素使用疗程、住院时间、住院费用等。结果血清降钙素原(PCT)监测对医院内获得性性肺炎的诊断的特异性高达100.0%,敏感性达97.62%。两组患者的抗生素使用时间、住院时间、住院费用、细菌耐药率,比较t分别为,P<0.05,差异具有统计学意义。结论血清降钙素原在医院内获得性肺炎的治疗中起到了指导性作用,能减少抗生素使用疗程、住院时间、住院费用,可作为指导抗菌治疗的指标。

Objective To look into the value of monitoring of serum procalcitonin in treating hospital-acquired pneumonia.Methods One hundred and sixty eight patients with hospital acquired pneumonia admiited by this hosptial were studied, and they were divided into the observation group and the control group according to the availability of bacteria infection, patients in the observation group suffered from bacteria infectious pneumonia patients and they were subject to antibacterial treatment according to monitoring results of serum procalcitonin, patients in the control group suffered from non-bacteria infectious pneumonia, and they were subject to routine anti-infection treatment, clinical efficacy of patients in two groups were compared and analyzed.Results The specificity of the monitoring of serum procalcitonin（PCT） monitoring in the diagnosis of nosocomial acquired pneumonia hit as high as 100.0%, and the sensitivity hit 97.62%. The comparison in PCT level of patients in two gorups before and after the treatment hit 13.1692 and 7.9565 respectively, the average value of p was less than 0.05, and the difference was statistically significant.Conclusion The serum procalcitonin plays the guiding function in the treatment of hospital acquired pneumonia, and delivers better therapeutic efficacy when compared to traditional method, being qualified to serve as the index to guide antibacterial therapy.