不同剂量rt-PA静脉溶栓治疗急性脑梗死的临床疗效

The curative effect of different doses of rt-PA intravenous thrombolysis treating patients with acute cerebral infarction

目的探讨不同剂量rt-PA静脉溶栓治疗急性脑梗死的疗效。方法随机选取我院2010-02—2012-11收治的急性脑梗死患者82例为研究对象,分为小剂量(0.6mg/kg)静脉溶栓A组(41例),大剂量(0.9mg/kg)B组(41例),采用神经功能缺损评分(NIHSS)评价2组疗效,对比并发症发生率。结果 2组NIHSS评分均优于治疗前(P<0.05),但治疗后各阶段2组无显著差异(P>0.05);不良反应发生率B组明显高于A组(P<0.05)。结论 rt-PA静脉溶栓可显著改善急性脑梗死患者预后,但治疗效果与剂量大小关联性不显著,大剂量rt-PA会增加出血风险。

Objective To investigate the the curative effect of different doses of rt-PA intravenous thrombolysis treating patients with acute cerebral infarction.Methods 82 patients with acute cerebral infarction in our hospital from February 2010 to November 2012 were randomly divided into the intravenous thrombolysis group A（n=41,0.6mg/kg）and the intravenous thrombolysis group B（n=41,0.9mg/kg）.The neural function defect score（NIHSS）and complications incidence of two groups were compared.Results The NIHSS of two groups after treatment were more than these before treatment,but had no significant difference in different stages of the two groups after treatment.The incidence of adverse reactions in group B was higher than that in group A.Conclusion Rt-PA intravenous thrombolysis can significantly improve the prognosis of patients with acute cerebral infarction,but no significant correlation between therapeutic effect and dose size.Large dose of rt-PA can increase the bleeding risk.