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鼻眼脑型毛霉菌1例典型病例并文献复习

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摘要 目的探讨鼻眼脑型毛霉菌病的临床特征及诊断、治疗。方法分析本院1例鼻眼脑型毛霉菌病的临床资料及万方数据库以"鼻脑型毛霉菌"为关键词收集到的19例病例的临床资料。结果共20例患者,发病年龄18-77岁,平均(48.3±16.48)岁,男12例,女8例,男女比例3:2,糖尿病17例,合并酮症酸中毒11例,肝硬化2例,肾移植2例,血液系统疾病2例,过敏性紫癜1例,临床以发热、头痛、意识障碍及伴面部特征性肿胀坏疽、突眼及视力下降为主要表现,部分合并明确的脑梗死,死亡14例。结论该病是一种严重的致死性机会感染,以青壮年多见,糖尿病并酮症酸中毒是主要危险因素,面部可有特征性感染病灶有助于诊断,分泌物涂片及鼻腔坏死组织病理可以确诊,病死率极高,合并颅内感染意味预后不良。
出处 《中国实用神经疾病杂志》 2014年第18期141-142,共2页 Chinese Journal of Practical Nervous Diseases
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