期刊文献+

维生素D辅助治疗婴幼儿喘息性肺炎的临床研究 被引量:12

下载PDF
导出
摘要 目的探讨喘息性肺炎患儿血清碱性磷酸酶、25-(OH)D3及IgA水平的变化及临床疗效。方法将80例喘息性肺炎患儿随机分为维生素D治疗组及非维生素D治疗组,均给予抗感染及对症治疗,同时维生素D治疗组给予补充维生素D治疗1个月,治疗前及治疗后1个月分别检测血清碱性磷酸酶、25-(OH)D3及IgA水平,同时记录患儿临床疗效。结果 (1)治疗1个月后,喘息性肺炎维生素D治疗组碱性磷酸酶、25-(OH)D3及IgA水平均优于治疗前,差异有统计学意义(P<0.05)。(2)维生素D治疗组气促喘息消失时间、心率恢复正常时间、哮鸣音消失时间、住院时间较非维生素D治疗组明显降低,差异有统计学意义(P<0.05)。(3)维生素D治疗组总有效率97.5%(39/40),明显高于非维生素D治疗组75.0%(30/40),差异有统计学意义(P<0.01)。结论辅以足量的维生素D可缩短喘息性肺炎病程,改善疗效,提高患儿免疫力,维生素D缺乏可能为喘息性肺炎潜在病因。
出处 《中国中西医结合儿科学》 2014年第5期451-453,共3页 Chinese Pediatrics of Integrated Traditional and Western Medicine
  • 相关文献

参考文献8

二级参考文献67

  • 1张武,张蕾,张婕,赵庆云,伏晓红.兰州城区太阳紫外辐射及其与空气污染的关系[J].兰州大学学报(自然科学版),2004,40(5):100-105. 被引量:30
  • 2马兰,侯安存,吕芳,卢炎.喘息与非喘息型病毒性肺炎患儿淋巴细胞亚群的研究[J].中国实用儿科杂志,2006,21(8):577-580. 被引量:6
  • 3中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南.中华结核和呼吸杂志,2008,:250-250.
  • 4Borges MC,Martini LA,Rogero MM.Current perspectives on vitamin D,immune system,and chronic diseases. Nutrition,2011,27:399-404.
  • 5Sutherland ER,Goleva E,Jackson LP,et al.Vitamin D levels,lung function,and steroid response in adult asthma.Am J Respir Crit Care Med,2010,181:699-704.
  • 6Bener A,Ehlayel MS,Tulic MK,et al.Vitamin D Deficiency as a Strong Predictor of Asthma in Children. Int Arch Allergy Immunol,2011,157:168-175.
  • 7Majak P,Olszowiec-Chlebna M,Smejda K,et al.Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection.J Allergy Clin Immunol,2011,127:1294-1296.
  • 8Carroll KN,Gebretsadik T,Larkin EK,et al.Relationship of maternal vitamin D level with maternal and infant respiratory disease.Am J Obstet Gynecol,2011,205:215.
  • 9Morales E,Romieu I,Guerra S,et al.Maternal Vitamin D Status in Pregnancy and Risk of Lower Respiratory Tract Infections,Wheezing,and Asthma in Offspring.Epidemiology,2012,23:64-71.
  • 10Robinson DS.Regulatory T cells and asthma.Clin Exp Allergy,2009,39:1314-1323.

共引文献2041

同被引文献104

  • 1无.儿童社区获得性肺炎管理指南(试行)(下)[J].中华儿科杂志,2007,45(3):223-230. 被引量:207
  • 2John H. White.??Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future(J)Journal of Steroid Biochemistry and Molecular Biology . 2010 (1)
  • 3Yuka Misawa,Atsushi Baba,Susumu Ito,Miyuki Tanaka,Masaaki Shiohara.??Vitamin D 3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns(J)International Journal of Hematology . 2009 (5)
  • 4Daniel Bikle.??Nonclassic Actions of Vitamin D(J)The Journal of Clinical Endocrinology & Metabolism . 2009 (1)
  • 5John H. Lee,James H. O’Keefe,David Bell,Donald D. Hensrud,Michael F. Holick.??Vitamin D Deficiency(J)Journal of the American College of Cardiology . 2008 (24)
  • 6Michael F. Holick.??High Prevalence of Vitamin D Inadequacy and Implications for Health(J)Mayo Clinic Proceedings . 2006 (3)
  • 7Virender K Rehan,John S Torday,Sara Peleg,Lynn Gennaro,Paul Vouros,James Padbury,D Sunita Rao,G Satyanarayana Reddy.??1α,25-Dihydroxy-3-epi-vitamin D 3 , a natural metabolite of 1α,25-dihydroxy vitamin D 3 : production and biological activity studies in pulmonary alveolar type II cells(J)Molecular Genetics and Metabolism . 2002 (1)
  • 8Ove B?ck,Hans K:Son Blomquist,Olle Hernell,Berndt Stenberg.Does Vitamin D Intake During Infancy Promote the Development of Atopic Allergy?. Acta Dermato Venereologica . 2009
  • 9Abul-Ainine A,Luyt D.Short term effects of adrenaline in bronchiolitis: a randomised controlled trial. Archives of Disease in Childhood . 2002
  • 10D. A. Hughes,R. Norton.Vitamin D and respiratory health. Clinical and Experimental . 2009

引证文献12

二级引证文献35

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部