摘要
制备了不同乳糖取代度的乳糖化油酰壳聚糖(Lac-OCH)。通过粘度法检测了Lac-OCH的流变学特性;通过荧光法研究了Lac-OCH在溶液中的自聚集行为,随着乳糖取代度升高,临界聚集浓度(CAC)值升高;采用超声法制备Lac-OCS纳米体系;采用透射电镜观察Lac-OCH纳米球呈现椭球棒状,粒径约为200 nm;研究了Lac-OCH负载药物阿霉素后的包封率和体外释放情况。
The lactose-oleoylchitosan（ Lac-OCH ）with different degree of substitution（ DS ）of lactose was PrePared. The rheological features of Lac-OCH were investigated by viscosity assay. The CAC value in-creased along with the increase of DS of lactose. The Lac-OCH nanoParticles showed dense,axiolitic tex-ture and the average diameter was aPProximate 200 nm. The sustained-release characteristics of Lac-OCH nanoParticles were studied using doxorubicin（ DOX）as model drug. The results revealed the Promising Po-tential of amPhiPhilic Lac-OCH as drug carrier.
出处
《应用化工》
CAS
CSCD
2014年第7期1214-1217,共4页
Applied Chemical Industry
基金
河北省自然科学基金-石药集团医药联合研究基金(CSPC
E2013201205)
河北省高等学校科学技术研究青年基金项目(Q2012140)
2014年保定市科学技术研究与发展指导计划(14ZF052)
关键词
乳糖化油酰壳聚糖
纳米微球
阿霉素
体外释放
lactose-oleoylchitosan
nanoParticles
doxorubicin
drug delivery system
