新型查尔酮类衍生物的合成

Synthesis of a novel chalcone derivative

以苯乙酮为原料进行自身羟醛缩合反应,生成1,3-二苯基-2-丁烯-1-酮,然后在BPO引发下,用NBS进行溴代,经水解后生成新型查尔酮衍生物(Z)-1,3-二苯基-4-羟基-2-丁烯-1-酮,并采用IR、ESI-MS、1H NMR对其结构进行了表征。考察羟醛缩合反应催化剂、温度、物料配比等因素对合成的影响。结果表明,缩合反应的较佳条件是∶n(苯乙酮)∶n(氯化亚砜)=1.2∶1,反应温度为室温,反应时间为30 min,缩合产物收率达72%。

A new chalcone derivative was PrePared from acetoPhenone in the catalysis of thionyl chloride, and then in the BPO induced by bromination,hydrolyzed to generate the target Product. The structure identification was Performed by IR,ESI-MS,1 H NMR. The affecting factors of the condensation reaction were discussed so as to select the best reaction conditions. The results show that the better reaction condi-tions of the aldol condensation are as follows：n（acetoPhenone）：n（SOCl2）= 1. 2：1,the reaction tem-Perature is room temPerature,the reaction time is 30 min,and the aldol reaction yield can reach 72%.