垂体腺瘤手术中运用内镜与显微镜的对比性研究

Comparative Study of the Use of Endoscope and Microscope Operation of Pituitary Adenoma

目的:探讨垂体腺瘤手术中运用内镜与显微镜治疗的疗效。方法:选取2010年1月-2014年1月笔者所在医院收治的288例垂体腺瘤患者,采用随机数字表法将其分为内镜组(122例)和对照组(166例),内镜组采用经鼻蝶窦内镜垂体腺瘤切除术,对照组采用经鼻蝶窦显微镜切除术,比较两组手术效果、并发症发生情况及症状改善情况。结果:内镜组平均手术时间和住院时间分别为(66.1±8.9)min、(4.3±1.8)d,均明显低于对照组的(81.3±13.6)min、(8.6±3.1)d,差异有统计学意义(P<0.05)。内镜组肿瘤全切除105例(86.1%),术后出现并发症6例(4.9%);对照组肿瘤全切除125例(75.3%),术后出现并发症69例(41.6%),两组比较差异均有统计学意义(P<0.05)。内镜组头痛消失、视力恢复、生长激素水平和泌乳素水平恢复率均明显高于对照组,差异有统计学意义(P<0.05)。结论:与经鼻蝶窦显微镜镜垂体腺瘤切除术相比,采用内镜切除垂体腺瘤更有优势。

Objective：To explore the effect of using the endoscope and microscope operation in the treatment of pituitary adenoma. Method：288 patients with pituitary adenoma were treated from January 2010 to January 2014 in author’s hospital,they were randomly divided into endoscopic group（122 cases） and control group（166 cases）,endoscopic group was treated by transsphenoidal endoscopic pituitary adenoma resection,control group was treated by transsphenoidal microscopicresection,complication,operation effect between the two groups and the incidence of symptoms to improve the situation were compared.Result：Endoscopic group average operation time and hospitalization time were （66.1±8.9）min,（4.3±1.8）d,were significantly lower than the control group （81.3±13.6）min,（8.6±3.1）d,the differences were statistically significant（P〈0.05）. Endoscopic group total tumor resection in 105 cases（86.1%）,6 cases of postoperative complications（4.9%）;the control group total tumor resection in 125 cases（75.3%）,postoperative complications occurred in 69 cases（41.6%）,the differences between the two groups were statistically significant（P〈0.05）. Endoscopic group headache disappeared,the recovery of visual acuity,growth hormone and prolactin level recovery rate were significantly higher than that in control group,the differences were statistically significant（P〈0.05）. Conclusion：Compares transsphenoidal microscopic pituitary adenoma resection with endoscopic resection of pituitary adenoma,endoscopic resection of pituitary adenoma has more advantage.